摘要
The aim of this study was to evaluate the effects of associations and allele substitution of DNA single nucleotide polymorphism (SNP) on genes linked to appetite control (NPY and PDE3B) and ion transport (ITPR1 and TRPM3) of average daily gain (ADG), feed conversion ratio (FCR), residual feed intake (RFI), residual BW gain (RWG), residual intake and body weight gain (RIG) and dry matter intake (DMI) of Nellore (Bos indicus) cattle. We evaluated the DMI, body weight and ADG of two hundred fifty-one animals kept in feedlots. The data were used to calculate the FCR, RFI, RWG and RIG. The associations of these variables with four SNPs (one in each gene cited above) were analyzes and the effects of allele substitution were estimated using PROC MIXED of SAS 9.3. The SNPs showed no association in genes ITPR1, TRPM3 and NPY, but we observed a significant association (P≤0.05) and effect of allele substitution in one SNP in gene PDE3B with DMI, RFI and RIG. The SNPs evaluated are polymorphic in Nellore cattle and the gene PDE3B should be further studied because it seems to have effect on feed intake and efficiency.
摘要译文
链接到控制食欲（NPY和PDE3B）和离子转运的平均日增重（ITPR1和TRPM3）（ADG）对基因协会和DNA单核苷酸多态性（SNP）的等位基因替代，饲料转化率（FCR），剩余的采食量（RFI），剩余的体增重（RWG），残留量和体重增益（RIG）和内洛尔干物质摄入量（DMI）（瘤牛）牛。我们评估了DMI，体重251动物关在饲养场和日增重。该数据被用来计算FCR，RFI RWG和RIG。使用PROC MIXED SAS 9.3的估计这些变量与4个位点（一个在以上引用的每个基因）为分析和等位基因取代效应的关联。单核苷酸多态性显示，基因ITPR1，TRPM3和NPY没有任何关联，但我们观察到一个显著协会（P所评估的SNP位点是多态的内洛尔牛和基因PDE3B应进一步研究，因为它似乎对采食量和效率的影响。
M.H.A. Santana[a]; R.C. Gomes[b]; G.M. Ozawa[a]; H. Fukumasu[a]; S.L. Silva[a]; P.R. Leme[a]; P. Rossi Junior[c]; P.R.L. Pires[a]; P.A. Alexandre[a]; P.S. Oliveira[a]; F.V. Meirelles[a]; J.B.S. Ferraz[a]. Single nucleotide polymorphisms in genes linked to ion transport and regulation of appetite and their associations with weight gain, feed efficiency and intake of Nellore cattle[J]. Livestock Science, 2014,165: 33–36