期刊文献

DNA Methylation in Neurodegenerative Disorders 收藏

DNA甲基化在神经退行性疾病
原文求助 发布源
作者
Zihui Xu [1] [2] Xuekun Li [1]
作者单位
1. Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA 2. Division of Histology and Embryology, Department of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
关键词
DNA methylation ;Neurodegeneration ;Cognitive function ;Aging ;Alzheimer’s disease ;Parkinson’s disease ;Amyotrophic lateral sclerosis ;DNA demethylation
关键词译文
DNA甲基化;神经退行性疾病;认知功能;衰老;阿尔茨海默氏病;帕金森氏病;肌萎缩性侧索硬化; DNA去甲基化
发布日期
22 September 2012
页码
199-205
DOI
10.1007/s13670-012-0026-1
来源信息
Current Geriatrics Reports ISSN：e2196-7865, 2012年, 1卷, 4期, 199-205页
摘要
Epigenetic mechanisms are essential in a host of biological processes and many different human diseases. Epigenetic modifications include DNA methylation, histone modification, non-coding RNA, and nucleosome positioning. In neuronal systems, extensive studies have revealed important regulatory roles of DNA methylation in brain function, from the embryonic stage through the process of aging. Here we review recent evidence that DNA methylation is involved in aging, learning and memory, and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and CGG repeat-induced neurodegenerative disorders. We also explore the dynamics of DNA methylation. KeywordsDNA methylation Neurodegeneration Cognitive function Aging Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis DNA demethylation
摘要译文
表观遗传机制是在生物过程和许多不同的人类diseasesEpigenetic修饰的宿主必需包括DNA甲基化，组蛋白修饰，非编码RNA和核小体positioningIn神经元系统，广泛研究已经揭示在大脑DNA甲基化的重要的调节作用功能，从胚胎期通过agingHere的过程中，我们审查最近的证据表明，DNA甲基化参与老化，学习和记忆，和神经退行性疾病，包括老年痴呆症鈥檚症，帕金森鈥檚病，肌萎缩侧索硬化症和CGG重复诱导的神经退行性disordersWe还探讨了DNA甲基化KeywordsDNA甲基神经退行性疾病的认知功能老化阿尔茨海默鈥檚病帕金森鈥檚疾病肌萎缩性脊髓侧索硬化症DNA去甲基化动态
Zihui Xu [1] [2] Xuekun Li [1]. DNA Methylation in Neurodegenerative Disorders[J]. Current Geriatrics Reports, 2012,1(4): 199-205