摘要
Background
Controlled ovarian hyperstimulation (COH) combined with intrauterine insemination (IUI), using a volume of 0.5 ml of inseminate is commonly offered to couples with non-tubal sub fertility. Another method is Fallopian tube sperm perfusion (FSP) which is based on a pressure injection of 4 ml of sperm suspension while attempting to seal the cervix to prevent semen reflux. This technique ensures the presence of higher sperm density in the fallopian tubes at the time of ovulation than standard IUI. The aim of this study was to compare the efficiency of standard intrauterine insemination (IUI) and Fallopian tube sperm perfusion (FSP) in the treatment of non-tubal infertility. Methods
200 consecutive patients with infertility in 404 stimulated cycles were included in the study. Those randomized to standard IUI included 100 patients in 184 cycles [158 clomiphene citrate/human menopausal gonadotrophin cycles and 26 Letrozole/FSH cycles exclusively for polycystic ovarian disease patients] (group A). Patients subjected to FSP included 100 patients in 220 cycles (193 clomiphene citrate/human menopausal gonadotrophin cycles and 27 Letrozole/FSH cycles exclusively for polycystic ovarian disease patients] (group B). Swim up semen preparation technique was used in all cases. Insemination was performed in both groups 34–37 h after hCG administration. Standard IUI was performed using 0.5 ml of inseminate. In FSP 4 ml inseminate was used. Results
In group A (184 IUI cycles in 100 patients), 22 clinical pregnancies (presence of gestational sac with fetal cardiac activity) occurred (11.95% per cycle over four cycles). In group B, (220 cycles of FSP in 100 patients), 48 clinical pregnancies occurred (21.81% per cycle over four cycles) and this difference was statistically significant (p < 0.05). Conclusions
For non-tubal sub fertility, the results indicate clear benefit for FSP (Fallopian tube sperm perfusion) over IUI (Intrauterine insemination).
摘要译文
背景控制性超排卵（COH）联合宫腔内人工授精（IUI），使用0卷。5毫升授精的通常提供给夫妇与非输卵管子生育能力。另一种方法是输卵管精子灌注（FSP），它是基于一个压喷射的4毫升精子悬浮液，同时试图以密封子宫颈，以防止精液回流。这种技术可确保更高精子密度在输卵管在排卵比标准人工授精的时间的存在。本研究的目的是在非输卵管不孕症的治疗比较的标准宫腔内人工授精（IUI）和输卵管精子灌注（FSP）的效率。方法：连续200例不孕不育的404次刺激被纳入研究。TANDARD IUI纳入100例患者184周期[158克罗米芬/人绝经期促性腺激素周期和来曲唑26 / FSH周期专为多囊性卵巢疾病患者用药】（A组）。反恐执行局FSP纳入100例患者中220个周期（193克罗米芬/人绝经期促性腺激素周期和来曲唑27 / FSH周期专为多囊性卵巢疾病患者]（B组）。游了精液制备技术，在所有情况下使用。 hCG注射后34-37 h的两组进行授精。标准人工授精用0.5毫升授精的执行。在FSP4毫升授精使用。结果A组（184个周期IUI 100例），22临床妊娠（孕囊与胎儿心脏活动状况）发生（11。95％的速度在周期四个周期）。在B组，（FSP的100名患者220次），48临床妊娠发生（21。每个周期的81％，比4个周期），这差异有统计学显著（P结果显示为FSP（输卵管精子灌注）在IUI明显受益（人工授精）。
Col G.S. Shekhawat (Retd). Intrauterine insemination versus fallopian tube sperm perfusion in non-tubal infertility[J]. Medical Journal Armed Forces India, 2012,68(3): 226–230