摘要
Electropermeabilization is a method that uses electric field pulses to induce an electrically mediated reorganization of the plasma membrane of cells. Electrochemotherapy combines local or systemic administration of chemotherapeutic drugs such as bleomycin or cisplatin that have poor membrane permeability with electropermeabilization by direct application of electric pulses to the tumors. Preclinical studies have demonstrated excellent antitumor effectiveness of electrochemotherapy on different animal models and various tumor types, minimal toxicity, and safety of the procedure. Based on results of preclinical studies, clinical studies were conducted in human patients, which demonstrated pronounced antitumor effectiveness of electrochemotherapy with 80–85% objective responses of the treated cutaneous and SC tumors. Clinical studies in veterinary oncology have demonstrated that electrochemotherapy is very effective in the treatment of cutaneous and SC tumors of different histologic types in cats, dogs, and horses. The results of these studies have also demonstrated approximately 80% long-lasting objective responses of tumors treated by electrochemotherapy. Primary tumors of different histologic types were treated. Electrochemotherapy in veterinary oncology has future promise to be highly effective, and could be used to treat primary or recurrent solitary or multiple cutaneous and SC tumors of different histology or as an adjuvant treatment to surgery.
摘要译文
Electropermeabilization是使用电场脉冲来诱导细胞的质膜的电介导的重组的方法。化疗药物如博来霉素或顺铂具有差的膜渗透性与electropermeabilization通过直接施用的电脉冲对肿瘤ystemic施用。临床前研究已经证明电化学对不同的动物模型和不同的肿瘤类型，毒性极小，并且过程的安全性优异的抗肿瘤效果。基于临床前研究的结果，临床研究在人类患者进行的，这表明电化学的明显的抗肿瘤效果与处理过的皮肤和SC肿瘤的80％-85％的目标的响应。在兽医肿瘤学临床研究已经表明，电化学是非常有效的不同组织学类型的猫，狗皮肤和SC肿瘤的治疗，和马。这些研究的结果还表明约80％的长效通过电化学治疗的肿瘤的客观反应。不同病理类型的原发性肿瘤治疗。电化学兽医肿瘤学有前途的承诺是非常有效的，并可以用于治疗不同的组织学或作为辅助治疗，以外科手术的伯或复发孤或多个皮肤和SC肿瘤。
M. Cemazar[1]; Y. Tamzali[4]; G. Sersa[1]; N. Tozon[2]; L.M. Mir[5]; D. Miklavcic[3]; R. Lowe[6] and J. Teissie[7];. Electrochemotherapy in Veterinary Oncology[J]. Journal of Veterinary Internal Medicine, 2008,22(4): 826-831