摘要
Metabolic disease encompasses several disorders including obesity, type 2 diabetes, and dyslipidemia. Recently, the incidence of metabolic disease has drastically increased, driven primarily by a worldwide obesity epidemic. Transgenerational inheritance remains controversial, but has been proposed to contribute to human metabolic disease risk based on a growing number of proof-of-principle studies in model organisms ranging from Caenorhabditis elegans to Mus musculus to Sus scrofa. Collectively, these studies demonstrate that heritable risk is epigenetically transmitted from parent to offspring over multiple generations in the absence of a continued exposure to the triggering stimuli. A diverse assortment of initial triggers can induce transgenerational inheritance including high-fat or high-sugar diets, low-protein diets, various toxins, and ancestral genetic variants. Although the mechanistic basis underlying the transgenerational inheritance of disease risk remains largely unknown, putative molecules mediating transmission include small RNAs, histone modifications, and DNA methylation. Due to the considerable impact of metabolic disease on human health, it is critical to better understand the role of transgenerational inheritance of metabolic disease risk to open new avenues for therapeutic intervention and improve upon the current methods for clinical diagnoses and treatment.
摘要译文
代谢性疾病包括几种疾病，包括肥胖症，2型糖尿病，和dyslipidemiaRecently，代谢性疾病的发病率急剧上升，主要由全球肥胖epidemicTransgenerational继承仍然是有争议的带动下，已经提出了有助于基于在模式生物越来越多证明型原理的研究范围从线虫到小家鼠到野猪人体代谢疾病的风险总的来说，这些研究表明，遗传风险表观遗传学上从父传递到子代多代在不存在持续暴露于触发刺激初始触发器的不同品种可诱发跨代传承，包括高脂肪或高糖饮食，低蛋白饮食，各种毒素，和祖先的遗传变异虽然疾病风险的跨代传承背后的机械基础仍然是未知，推测分子介导传输包括小分子RNA，组蛋白修饰和DNA methylationDue代谢疾病对人体健康的相当大的影响，nderstand的代谢性疾病的风险跨代继承的作用，以打开新的途径为治疗性干预和改进对临床诊断和治疗的当前的方法
Rachel Stegemann[a]; David A. Buchner[a][b]. Transgenerational inheritance of metabolic disease[J]. Seminars in Cell & Developmental Biology, 2015,43: 131–140