期刊文献

Vitamin D and Dysfunctional Adipose Tissue in Obesity 收藏

维生素D和肥胖的功能失调性脂肪组织
原文求助
作者
Edita Stokić, MD, PhD1⇑ Aleksandar Kupusinac, PhD2 Dragana Tomic-Naglic, PhD1 Dragana Smiljenic, MD3 Branka Kovacev-Zavisic, MD, PhD1 Biljana Srdic-Galic, PhD3 Sanja Soskic, MSc4 Esma R. Isenovic, PhD4 [1]
作者单位
[1]1Medical Faculty in Novi Sad, Clinical Center of Vojvodina, Novi Sad, Serbia 2Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia 3Department of Anatomy, Medical Faculty, University of Novi Sad, Novi Sad, Serbia 4Laboratory for Molecular Genetics and Radiobiology, Institute of Nuclear Sciences “Vinca”, University of Belgrade, Belgrade, Serbia
关键词
vitamin D; dysfunctional adipose tissue; obesity; adipocytokine;
关键词译文
维生素D;功能失调的脂肪组织;肥胖;脂肪细胞因子;
页码
613-618
来源信息
Angiology: The Journal of Vascular Diseases ISSN：0003-3197, 2015年, 66卷, 7期, 613-618页
摘要
Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We evaluated the relation between vitamin D and adipocytokines derived from adipose tissue. We studied 50 obese individuals who were classified into different subgroups according to medians of observed anthropometric parameters (body mass index, body fat percentage, waist circumference, and trunk fat mass). There was a negative correlation between vitamin D level and leptin and resistin (r = −.61, P < .01), while a positive association with adiponectin concentrations was found (r = .7, P < .001). Trend estimation showed that increase in vitamin D level is accompanied by intensive increase in adiponectin concentrations (growth coefficient: 12.13). In conclusion, a positive trend was established between vitamin D and the protective adipocytokine adiponectin. The clinical relevance of this relationship needs to be investigated in larger studies.
摘要译文
维生素D缺乏症和功能失调的脂肪组织参与心脏代谢紊乱（例如，高血压，胰岛素抵抗，2型糖尿病，肥胖，和血脂异常）。我们评估维生素D与脂肪组织来源的脂肪细胞因子之间的关系。我们研究了50个肥胖者根据观察的人体测量参数（体重指数，体脂百分比，腰围，和躯干脂肪量）。维生素D水平与瘦素，抵抗素呈负相关（r \x3d -61，P 0.01），与脂联素浓度呈正相关（r \x3d7，P .001）。趋势估计显示维生素D水平的增加伴随着脂联素浓度的强烈增加（生长系数：12.13）。结论是，维生素D与保护性脂肪细胞因子脂联素呈正相关。这种关系的临床意义需要在更大的研究中进行调查。
Edita Stokić, MD, PhD1⇑ Aleksandar Kupusinac, PhD2 Dragana Tomic-Naglic, PhD1 Dragana Smiljenic, MD3 Branka Kovacev-Zavisic, MD, PhD1 Biljana Srdic-Galic, PhD3 Sanja Soskic, MSc4 Esma R. Isenovic, PhD4 [1]. Vitamin D and Dysfunctional Adipose Tissue in Obesity[J]. Angiology: The Journal of Vascular Diseases, 2015,66(7): 613-618