期刊文献

Germ cell suicide: new insights into apoptosis during spermatogenesis 收藏

生殖细胞自杀：新的见解凋亡精子发生过程

原文求助发布源

作者

Cristin G. Print[1,†] and Kate Lakoski Loveland[2,*];

作者单位

1 Reproductive Molecular Research Group, Department of Pathology, Cambridge University, Cambridge UK. 2 Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia.

发布日期

24 APR 2000

页码

423-430

DOI

10.1002/(SICI)1521-1878(200005)22:5<423::AID-BIES4>3.0.CO;2-0

来源信息

BioEssays ISSN：0265-9247, 2000年, 22卷, 5期, 423-430页

摘要

Mature sperm are the product of a precisely regulated developmental sequence in which germ cell proliferation, differentiation, self-renewal and apoptosis are carefully controlled. The control of germ cell apoptosis during spermatogenesis is especially important. It is mediated by signals derived from the Sertoli cells with which each germ cell is closely associated, as well as by signals originating outside the testis. A greater understanding of these signals is emerging from studies of the spermatogenic defects of genetically modified animals. In particular, the intracellular signaling cascades which ultimately determine germ cell fate are being illuminated by recent studies of the Bcl-2 protein family. This review summarises the crucial role which stringently regulated apoptosis plays in the production of male gametes. BioEssays 22:423—430, 2000. © 2000 John Wiley & Sons, Inc.

摘要译文

成熟精子是其中生殖细胞的增殖，分化，自我更新和细胞凋亡被仔细控制一个精确调节发育序列的乘积。生精细胞凋亡的精子发生过程的控制显得尤为重要。它是通过从支持细胞与每个生殖细胞紧密相关联，以及由信号睾丸以外地方的衍生信号介导的。这些信号的更大的理解是新兴的转基因动物的生精缺陷的研究。特别是，细胞内的信号级联反应，其最终决定生殖细胞命运正在照亮由最近的Bcl-2蛋白家族的研究。本文总结了其中严格规定凋亡戏剧生产雄配子的至关重要的作用。 BioEssays 22：423-430，2000。

Cristin G. Print[1,†] and Kate Lakoski Loveland[2,*];. Germ cell suicide: new insights into apoptosis during spermatogenesis[J]. BioEssays, 2000,22(5): 423-430