摘要
• Vitrified oocytes can retain a capacity for fertilisation and development which is similar to that of non-cryopreserved sibling oocytes. • More than 450 births have resulted from assisted conception with vitrified oocytes. • Controlled studies are required before the efficiency of vitrification can be fully assessed. • Aspects of methodology and safety still need to be resolved before vitrification is accepted unreservedly as part of conventional assisted conception. Learning objectives • To understand what is meant by vitrification and how it is achieved in practice. • To learn about the advantages and drawbacks of oocyte vitrification. • To have an overview of the success of assisted conception with vitrified oocytes. • To appreciate where questions remain to be answered about the methodology, safety and clinical outcome of vitrification. Ethical issues • Should assisted conception be offered with donor oocytes that have not undergone full quarantine similar to that required for donated sperm and embryos?
摘要译文
•玻化的卵母细胞可以保留一个容量为受精和发展，它类似于该非冻存同胞卵母细胞。•超过450胎起因于辅助受孕与玻璃化卵子。需要•受控研究之前玻璃化的效率，可以充分评估。•方法和安全方面仍然需要先解决玻璃化毫无保留地接受常规辅助受孕的一部分。学习目标•要了解什么是玻璃化以及它是如何在实践中取得的意思。 •要了解的优点和卵子玻璃化的弊端。•要人工受孕与玻璃化卵子成功的概述。 •要欣赏那里的问题尚待解答有关方法，安全和玻璃化的临床结果。道德问题•如果辅助受孕与那些没有经过充分的检疫类似要求捐献的精子和胚胎捐赠者提供卵子？
Maureen J Wood PhD. Vitrification of oocytes[J]. The Obstetrician & Gynaecologist, 2012,14(1): 45-49