摘要
The purpose of this review was to investigate the current knowledge about aflatoxin B1 (AFB1) and ochratoxin A (OTA) toxicity and the possible beneficial role of bioactive compounds by using in vitro and in vivo models. Although AFB1 and OTA were tested in a similar percentage, the majority of studies focused on nephrotoxicity, hepatotoxicity, immune toxicity and neurotoxicity in which oxidative stress, inflammation, structural damage and apoptosis were the main mechanisms of action reported. Conversely, several biological compounds were assayed in order to modulate mycotoxins damage mainly in the liver, brain, kidney and immune system. Among them, pumpkin, curcumin and fermented whey were the most employed. Although a clear progress has been made by using in vivo models, further research is needed to assess not only the toxicity of multiple mycotoxins contamination but also the effect of functional compounds mixture, thereby reproducing more realistic situations for human health risk assessment.
摘要译文
这篇综述的目的是研究当前关于黄曲霉毒素B1（AFB1）和ochratoxin A（OTA）毒性的知识，并通过使用体外和体内模型来研究生物活性化合物的可能有益作用。尽管AFB1和OTA以相似的百分比进行了测试，但大多数研究集中在肾毒性，肝毒性，免疫毒性和神经毒性上，其中氧化应激，炎症，结构损害和凋亡是作用的主要作用机制。相反，测定了几种生物化合物，以调节主要在肝脏，脑，肾脏和免疫系统中损害霉菌毒素。其中，南瓜，姜黄素和发酵的乳清最受生物的工作。尽管使用体内模型已经取得了明显的进展，但仍需要进一步的研究来评估多种霉菌毒素污染的毒性，还要评估功能化合物混合物的效果，从而重现了人类健康风险评估的更现实情况。
Lara Manyes. In vitro and in vivo assessment of AFB1 and OTA toxic effects and the beneficial role of bioactive compounds. A systematic review[J]. Food Chemistry, 2024,447: 138909