摘要
Ferroptosis is a recently identified type of regulated cell death characterized by lipid peroxidation and redox-active iron accumulation. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial regulator of genes involved in glutathione biosynthesis, antioxidant responses, lipid metabolism, and iron metabolism, contributing to the evasion of ferroptosis. Inhibiting the Nrf2 pathway has been shown to sensitize cancer cells to ferroptosis. In head and neck cancer cells, we found that activation of the Nrf2-antioxidant responsive element pathway leads to ferroptosis resistance, and inhibiting this pathway reverses ferroptosis evasion. Our study suggests that modulating the Nrf2 pathway could be a promising strategy to overcome resistance in cancer therapy for head and neck cancer. Further research is required to investigate the potential of ferroptosis induction in therapy-resistant head and neck cancer. Targeting Nrf2 through ferroptosis-based cancer therapy may be a novel and effective approach to reverse the resistance of head and neck cancer therapy.
摘要译文
铁凋亡是最近鉴定出的调节细胞死亡类型，其特征是脂质过氧化和氧化还原活性铁的积累。核因子红系2相关因子2（NRF2）是参与谷胱甘肽生物合成，抗氧化剂反应，脂质代谢和铁代谢的基因的关键调节因子，这有助于逃避溢血。抑制NRF2途径已被证明可以使癌细胞敏感到逆转录病。在头颈癌细胞中，我们发现NRF2抗氧化剂的响应元件途径的激活会导致耐铁的耐药性，并抑制该途径会逆转逃避铁的逃避。我们的研究表明，调节NRF2途径可能是克服癌症治疗头颈癌的耐药性的有前途的策略。需要进一步的研究来研究耐药头和颈部癌中铁凋亡诱导的潜力。通过基于铁铁病的癌症治疗靶向NRF2可能是一种新型有效的方法，可以扭转头颈癌疗法的耐药性。
Jong-Lyel Roh. Nrf2 targeting in overcoming ferroptosis evasion in head and neck cancer[J]. Biochemical and Biophysical Research Communications, 2023,671: 225-228