摘要
The present study aimed to evaluate whether a moderate dose of aflatoxin B1 in pigs' diet interferes with pigs' growth and health in the nursery phase and whether an anti-mycotoxin mixture minimizes the adverse effects of the toxin. One blend with Saccharomyces cerevisiae lysate, zeolite, silicon dioxide, propylene glycol, Carduus marianus extract, soy lecithin, and carbonate was used as an anti-mycotoxin. Four treatments, with six repetitions per treatment and three pigs/pen: Afla0-AntiMyc0 - negative control (without aflatoxin); Afla500-AntiMyc0 - positive control (500 ppb of aflatoxin); Afla0-AntiMyc1000 - 1000 mg/kg of anti-mycotoxin blend; Afla500-AntiMyc1000 - 500 ppb aflatoxin +1000 mg/kg of anti-mycotoxin blend. It was observed that pigs in the positive control (Afla500-AntiMyc0) had lower body weight and weight gain when compared to the other treatments during the experimental period. Also, pigs from Afla500-AntiMyc0 had lower feed intake between days 1–20 and 1 to 30 than Afla0-AntiMyc0. The pigs from Afla500-AntiMyc0 had higher levels of liver enzymes aspartate aminotransferase and alanine aminotransferase compared to other treatments. The pigs from Afla500-AntiMyc0 had higher villus height than the other treatments, while the folded size was smaller in this treatment. Crypts were deeper in the intestines of pigs in both treatments that consumed aflatoxin. In general, it is concluded that the intake of aflatoxin B1 by nursery pigs has negative impacts on the health and, consequently, the animals' growth performance; however, the addition of the contaminated feed with an anti-mycotoxin blend was able to protect the pigs, minimizing the adverse effects caused by the mycotoxin.
摘要译文
本研究旨在评估猪饮食中的中等剂量的黄曲霉毒素B1是否会干扰托儿所的猪的生长和健康，以及抗肌毒素混合物是否可以最大程度地减少毒素的不良影响。一种与酿酒酵母裂解物，沸石，二氧化硅，丙烯乙二醇，甲壳虫提取物，大豆卵磷脂和碳酸盐的混合物。四种治疗方法，每次治疗六次重复和三头猪/笔：AFLA0-抗抗激素 - 阴性对照（不含黄曲霉毒素）；AFLA500 -ANTIMYC0-阳性对照（500 ppb的黄曲霉毒素）；AFLA0-ANTIMYC1000-1000 mg/kg抗氧毒素混合物；AFLA500-ANTIMYC1000-500 PPB黄曲霉毒素+1000 mg/kg抗肌毒素混合物。观察到与实验期间的其他治疗相比，阳性对照中的猪（AFLA500-ANTIMYC0）的体重和体重增加较低。同样，来自Afla500-Antimyc0的猪在第1-20天到1至30天之间的饲料摄入量低于AFLA0-ANTIMYC0。与其他治疗相比，来自AFLA500-ANTIMYC0的猪具有较高水平的肝酶天冬氨酸氨基转移酶和丙氨酸氨基转移酶。来自Afla500-Antimyc0的猪的绒毛高度高于其他治疗方法，而在这种处理中，折叠尺寸较小。在两种食用黄曲霉毒素的治疗方法中，猪的肠道中的隐窝都更深。总的来说，得出的结论是，苗圃猪对黄曲霉毒素B1的摄入对健康有负面影响，因此，动物的生长表现。但是，加入抗肌毒素混合物的污染饲料能够保护猪，从而最大程度地减少了由霉菌毒素引起的不良反应。
Aleksandro S. Da Silva [b]. Nursery pigs fed with feed contaminated by aflatoxin B1 (Aspergillus flavus) and anti-mycotoxin blend: Pathogenesis and negative impact on animal health and weight gain[J]. Microbial Pathogenesis, 2024,186: 106474