摘要
Oxidative stress has been recognized as a key mechanism in the development of vascular damage, particularly atherosclerosis. In spite of substantial experimental evidence demonstrating reversal of endothelial dysfunction and prevention of atherosclerosis in experimental settings, no benefits have been observed in large clinical trials in which antioxidants have been given in high-risk patients for the prevention of cardiovascular events. Evaluation of the clinical relevance of the oxidative modification hypothesis requires identification of potential molecular targets of antioxidant interventions and effective antioxidant agents. Future research should necessarily consider quantification of interindividual variations in oxidative stress using appropriate biomarkers.
摘要译文
氧化应激被认为是在血管损伤发展的关键机制，尤其是动脉粥样硬化。尽管大量实验证据证明逆转血管内皮功能障碍和预防动脉粥样硬化的实验设置的，没有好处已在大规模临床试验，其中的抗氧化剂有高风险的病人被给予用于预防心血管事件的观察。评价的氧化修饰假说的临床相关的，需要鉴定抗氧化剂的干预和有效抗氧化剂的潜在分子靶点。未来的研究应该使用合适的生物标志物不一定考虑氧化应激的个体差异进行量化。
Pietro Minuz, Cristiano Fava and Luciano Cominacini. Oxidative stress, antioxidants, and vascular damage[J]. British Journal of Clinical Pharmacology, 2006,61(6): 774-777