摘要
The gut microbiota was reported to differ between children with autism spectrum disorder (ASD) and typically developing (TD) children, and dysbiosis of the gut microbiota in preterm infants is common. Here, we explored the characteristics of gut microbiota in children born preterm with ASD. We performed 16S rRNA gene sequencing using stool samples from ASD children born preterm and TD children born preterm. Alpha diversity was significantly greater in the ASD group. A comparison of beta diversity showed different clusters. Linear discriminant analysis effect size analysis revealed significantly more Firmicutes in the ASD group compared with the TD group. In conclusion, the gut microbiota in children born preterm differs between children with ASD and TD.
摘要译文
据报道，自闭症谱系障碍（ASD）和通常发育（TD）儿童的肠道菌群有所不同，早产儿中肠道微生物群的营养不良是常见的。在这里，我们探讨了与ASD出生的早产儿童中肠道菌群的特征。我们使用来自ASD儿童的早产和TD儿童早产的粪便样本进行了16S rRNA基因测序。ASD组的α多样性明显更大。Beta多样性的比较显示出不同的簇。与TD组相比，线性判别分析效应大小分析显示，ASD组中的公司更大。总之，ASD和TD儿童之间出生早产儿的肠道菌群不同。
Fujishiro; Sadayuki[1];Tsuji; Shoji[1];Akagawa; Shohei[1];Akagawa; Yuko[1];Yamanouchi; Sohsaku[1];Ishizaki; Yuko[1];Hashiyada; Masaki[2];Akane; Atsushi[2];Kaneko; Kazunari[1]. Dysbiosis in Gut Microbiota in Children Born Preterm Who Developed Autism Spectrum Disorder: A Pilot Study[J]. Journal of Autism and Developmental Disorders, 2023,53(10): 4012-4020