摘要
Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are major causes of death worldwide and are characterized by a progressive loss of specific neuronal cells. Although the discovery of new drugs for these neurodegenerative diseases is still challenging, in recent years, natural phlorotannins and bromophenols contained in marine sources have shown protective activities from different neurodegenerative disorders and, therefore, might be good candidates for the development of new drugs. Data shown in this chapter indicate a sustained body of evidence on the ability of edible seaweeds to modulate multi-mechanisms involved in the prevention of neurodegenerative diseases. However, some aspects to be further explored during the following years emerge from this review, apart from confirming the results derived from in vitro and in vivo studies, particularly human studies.
摘要译文
阿尔茨海默氏病和帕金森氏病等神经退行性疾病是全球死亡的主要原因，其特征是特定神经元细胞的逐渐丧失。尽管这些神经退行性疾病的新药仍然具有挑战性，但近年来，海洋来源中包含的天然菲洛氏蛋白素和溴苯酚已经显示出来自不同神经退行性疾病的保护活性，因此，可能是新药开发的良好候选者。本章中显示的数据表明，关于可食用海藻调节涉及预防神经退行性疾病的多种机制的能力的持续证据。但是，除了证实了体外和体内研究，尤其是人类研究的结果外，在接下来的几年中需要进一步探索一些方面。
Raquel Mateos. Neurodegenerative diseases. Marine Phenolic Compounds[M].NL: ELSEVIER, 2023: 473-493