摘要
The importance of macrophages as effectors of cell-mediated immunity to a variety of microorganisms is undisputed. These include many bacteria and fungi that behave as facultative intracellular parasites, such as Mycobacterium tuberculosis, Brucella, Listeria monocytogenes, Histoplasma, and Candida, and some viruses, including psittacosis, vaccinia, and herpes simplex. There is a good evidence that macrophages are important in resistance to some experimental virus infections. There is also some evidence that in man recovery and resistance to reinfection with some viruses are associated with the acquisition of delayed-type hypersensitivity and hence, by implication, cell-mediated immunity; and that depression of cell-mediated immunity is associated with susceptibility to reinfection. Macrophages apparently are required for the induction of cell-mediated immune responses: adherent cells are necessary for the generation of cytolytic T cells in vitro and macrophage associated antigens are highly potent in inducing cell-mediated immunity in vivo.
摘要译文
巨噬细胞作为细胞介导的免疫对多种微生物的影响的重要性无可争议。其中包括许多细菌和真菌，表现为兼性细胞内寄生虫，例如结核分枝杆菌，布鲁氏菌，李斯特菌单核细胞生成，组织血糖和念珠菌，以及一些病毒，包括鹦鹉学疾病，疫苗和单纯疱疹。有一种很好的证据表明巨噬细胞对某些实验病毒感染的抗性很重要。还有一些证据表明，在人类的回收和对耐药性的抵抗力与一些病毒有关的延迟型超敏反应相关，因此通过暗示，细胞介导的免疫;并且细胞介导的免疫力抑制与易感性有关。巨噬细胞显然是诱导细胞介导的免疫应答所必需的：粘附细胞是在体外产生细胞溶解的T细胞所必需的，并且巨噬细胞相关抗原在体内诱导细胞介导的免疫方面是高效的。
D.S. Nelson. Macrophages As Effectors Of Cell-Mediated Immunity. Phagocytes and Cellular Immunity[M].UK: Taylorfrancis, 2020: 57-80