摘要
Supramolecular polymers based on cyclodextrins (CDs) have inspired interesting and rapid developments as novel biomaterials in a broad range of drug and gene delivery applications, due to their low cytotoxicity, controllable size, and unique architecture. This review will summarize the potential applications of polyrotaxanes in the field of drug delivery and gene delivery. Generally, cyclodextrin-based biodegradable polypseudorotaxane hydrogels could be used as a promising injectable drug delivery system for sustained and controlled drug release. Temperature-responsive, pH-sensitive, and controllable hydrolyzable polyrotaxane hydrogels have attracted much attention because of their controllable properties, and the self-assembly micelles formed by amphiphilic copolymer threaded with CDs could be used as a carrier for controlled and sustained drug release. Polyrotaxanes with drug or ligand conjugated CDs threaded on a polymer chain with a biodegradable end group could be useful for controlled and multivalent targeted delivery. In the field of gene delivery, cationic polyrotaxanes consisting of multiple OEI-grafted CDs threaded on a block copolymer chain are attractive non-viral gene carries due to the strong DNA-binding ability, low cytotoxicity, and high gene delivery capability. Furthermore, cytocleavable end-caps were introduced in the polyrotaxane systems in order to ensure efficient endosomal escape for intracellular trafficking of DNA. The development of the supramolecular approach using CD-containing polyrotaxanes is expected to provide a new paradigm for biomaterials.
摘要译文
基于环糊精（CDS）的超分子聚合物在广泛的药物和基因递送应用中，在广泛的药物和基因递送应用中引发了有趣和快速的发展，这是由于它们的低细胞毒性，可控尺寸和独特的架构。本综述将总结多岩在药物递送和基因递送领域的潜在应用。通常，基于环糊精的可生物降解的息氨酸水凝胶可以用作可持续和受控药物释放的有希望的注射药物递送系统。温度响应性，pH敏感和可控水解的聚霉素水凝胶由于其可控性能而引起了很多关注，并且通过两亲共聚物形成的自组装胶束螺纹用CDS螺纹可用作受控和持续的药物释放的载体。具有可生物降解的端基的聚合物链上螺纹的药物或配体共轭Cds的多岩可用于控制和多价靶向递送。在基因递送领域中，由多个OEI接枝CDS螺纹上螺纹的阳离子聚键组成，其由于强的DNA结合能力，低细胞毒性和高基因递送能力而具有吸引人的非病毒基因。此外，在多岩系统中引入了细胞纤维可变的终帽，以确保有效的内体逸出用于细胞内运输DNA。预计使用含CD的多岩多岩的超分子方法的发展是为生物材料提供新的范例。
Jia Jing Li.1;Feng Zhao.1;Jun Li.1;2. Supramolecular Polymers Based on Cyclodextrins for Drug and Gene Delivery. Biofunctionalization of Polymers and their Applications[M].DE: Springer, 2011: 207-249