摘要
Integrated membrane processes are those that combine multiple separation sub-processes into a single-unit operation, with one or more of these sub-processes involving membrane(s) as the means for separation. This chapter reviews the application of integrated membrane processes in the area of bioseparations. Membrane-based processes are known to be benign to sensitive biological products and are generally more amenable to sterile processing of such products due to ease of material containment and minimal use of additives and reagents. Integrated membrane processes, which cut down the number of steps in a separation process, and thereby increase process efficiency and product recovery, are likely to be very attractive in the area of protein purification. The application of membranes in bioseparation has largely been focused around the purification of macromolecular biopharmaceuticals. Two types of membrane processes have dominated biological separations: microfiltration and ultrafiltration.
摘要译文
集成膜过程是那些组合多个分离的子过程成一个单一的单元操作，与一个或多个涉及膜（多个）作为separationThis章节的装置，这些子过程的回顾集成膜过程中的生物分离领域中的应用已知的良性敏感的生物制品和一般更适合于这类产品的无菌加工，由于材料易于控制和极少使用的添加剂和试剂的集成膜过程，其中削减工序数在分离过程，从而提高工艺效率和产品回收，很可能是在蛋白纯化领域非常有吸引力在生物分离膜的应用已经在很大程度上被重点围绕生物制药大分子的纯化两种类型的膜分离过程的主宰生物分离：微滤和超滤
Raja Ghosh. 2. Bioseparations Using Integrated Membrane Processes. Integrated Membrane Systems and Processes[M].US: Wiley, 2016: 23-34