摘要
Neurodegenerative diseases (ND) are a large group of pathologies characterized by the progressive loss of selective neurons population with various factors that trigger their pathogenesis. With time the research about these increases exponentially, therefore, in the present chapter, we focus only on the most recent clinical biomarkers reported for ND such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), Spinocerebellar ataxias (SCAs), and ischemic stroke that have age as a common risk factor. Since individuals become more vulnerable to develop some ND with age. Additionally, in the last section, we delve into the recent role of microbiota dysbiosis and probiotics consumption in age-related neurodegenerative diseases (ARND) and remark the importance of this relatively new and quite promising field for the development of new treatment strategies in the clinic.
摘要译文
神经退行性疾病（ND）是一大类病理，其特征是选择性神经元种群逐渐丧失，其各种因素触发了其发病机理。随着时间的流逝，对这些疾病的研究呈指数增长，因此，在本章中，我们仅关注针对ND报告的最新临床生物标志物，例如阿尔茨海默氏病（AD），帕金森氏病（PD），肌萎缩性侧索硬化症（ALS），脊髓小脑以年龄为常见危险因素的共济失调（SCAs）和缺血性中风。由于个体变得更容易随着年龄的增长而发展某些ND。此外，在上一节中，我们深入研究了微生物群失调和益生菌摄入在与年龄有关的神经退行性疾病（ARND）中的最新作用，并指出了这个相对较新且非常有前途的领域对于开发临床新治疗策略的重要性。
Nadia Alejandra Rivero-Segura.1;A. A. Guerrero-Cruz.1;O. S. Barrera-Vázquez.1. Age-Related Neurodegenerative Diseases: An Update. Clinical Genetics and Genomics of Aging[M].DE: Springer, 2020: 27-41