摘要
3D printing to many seems like childish and toy-like technique that can create various figurine from their favorite movie or play but nothing can be more far from truth than this thought that 3D printing is toy making machine. Today, there are many branches in 3D printing that has completely taken the world of science by storm. It can help create a live model of any tissue or organ that so far could not be created using traditional engineering techniques. This is life saver for people who are usually on wait list for organ transplantation for years or even decade in some cases and even when the donor tissue is available; the chance of successful integration and engraftment with the host is always less. This is usually due to host vs graft rejection, which gets worst over time. In case of 3D printed organ, it has no memory of any host, so the rate of engraftment rejection is lesser than any live donor tissue. The improvement in manufacturing technique and architecture allows creating spare parts but for human use. 3D printing is increasingly becoming indispensable in regenerative medicine since it accelerates work and significantly cuts down the cost involved in the treatment. As the technology grows, biomanufacturing using 3D printing is going to be a very powerful and useful tool in the future of regenerative medicine and in this chapter, details of the technique used and some mathematical modeling that allows to design an organ with all its intrinsic details are discussed.
摘要译文
3D打印许多似乎是幼稚和玩具的技术，可以从他们最喜欢的电影或戏剧创造各种小雕像，但没有什么可以比这一想法更远，这是3D打印是玩具制造机。今天，3D印刷中有许多分支机构完全促使了风暴世界的科学世界。它可以帮助创建任何组织或器官的实时模型，以便无法使用传统的工程技术创建。这是通常在某些情况下甚至十年等待器官移植的人甚至十年的人的救生人员，即使供体组织可用;与主机成功集成和植入的机会总是较少。这通常是由于主机与移植物抑制，这会随着时间的推移而变得最差。在3D印刷器官的情况下，它没有任何宿主的记忆，因此植入抑制率较小于任何活体组织。制造技术和架构的改进允许创建备件但用于人类使用。 3D印刷越来越变得不可或缺于再生医学，因为它加速了工作并显着降低了治疗所涉及的成本。随着该技术的增长，使用3D打印的生物制造将是未来再生医学的一个非常强大和有用的工具，在本章中，使用的技术和一些数学建模的细节，允许以其内在的细节设计器官讨论过。
Pierre C.Dromel a b ;DeeptiSingh b c ;. Biomanufacturing. 3D Printing Medicine Surgery[M].US: ELSEVIER, 2020: 137-170