摘要
A close relationship between immune regulation and neuropsychiatric disorders is becoming more apparent. Studies have now uncovered key mechanisms for stress to manifest as physiological maladaptations. Stress is a persistent issue with broad-ranging implications for the mental and physical health of society, including its broad impact on immune health. Evidence shows that stress activates pro-inflammatory cytokine pathways that contribute to the long-term dysregulation of the hypothalamus-pituitary-adrenal axis. Within the past decade, preclinical discoveries have demonstrated multigenerational impacts of stress transmitted via the male germ line. While similar epigenetic processes exist in humans, the occurrence of intergenerational epigenetic inheritance in humans remains highly controversial. However, there is mounting evidence that a parental history of stress can be a risk factor for developing anxiety and depressive traits, leading to a more recent hypothesis that the parental history of exposures to stress also influences offspring immune function via epigenetic inheritance. In this regard, greater progress has been made in understanding the maternal influence while little is known of the paternal contribution. In this review, we will discuss the potential for non-genetic environmental factors (e.g. stress exposures) to compromise the male germline epigenetic constitution (e.g. non-coding RNA content and extent of DNA methylation) resulting in a compromised immunological state of health of their offspring.
摘要译文
免疫调节与神经精神疾病之间的密切关系变得越来越明显。现在，研究发现了重力表现为生理适应不良的关键机制。压力是一个持续的问题，对社会的心理和身体健康有广泛的影响，包括其对免疫健康的广泛影响。有证据表明，应力激活促炎性细胞因子途径，这导致下丘脑 - 垂体 - 肾上腺轴的长期失调。在过去的十年中，临床前的发现表明了通过男性生殖系传播的压力的多代影响。尽管人类存在类似的表观遗传过程，但人类中代际表观遗传的发生仍然存在很大争议。但是，有越来越多的证据表明，父母的压力病史可能是发展焦虑和抑郁特征的危险因素，这导致了最近的假设，即父母承受压力的历史也通过表观遗传遗传来影响后代的免疫功能。在这方面，在理解孕产妇的影响方面取得了更大的进步，而对父亲的贡献知之甚少。在这篇综述中，我们将讨论损害男性种系表观遗传构成（例如非编码RNA含量和DNA甲基化程度）的非遗传环境因素（例如应力暴露）的潜力，从而损害了其健康免疫状态。后代。
Cyprien G. J. Guerrin, Mari Trompke & Terence Y. Pang[1];Cyprien G. J. Guerrin[2];Terence Y. Pang[3];Guenther Witzany [4]. Prospective Intergenerational Consequences of Paternal Stress Experiences on Offspring Immune Health. Epigenetics in Biological Communication [M].DE: Springer, 2024: 233-253