摘要
Neurological disorders are ranked as a leading disorder under the subgroup of disability-adjusted life years (DALYs) in 2015 under the global burden of diseases and second highest leading cause of death. Many diseases other than neurological diseases could also lead to neurodegenerative effects in their later progressive stages. This kind of neuronal loss in the central nervous system has led to prominent functional disability and is responsible for chronic neurodegenerative disease pathology such as Alzheimer's, Parkinson's, and multiple sclerosis diseases worldwide. Till date, a wide range of drugs are available for the control and treatment of neurodegenerative diseases, but the outcome of this is presently unsatisfactory. Thus, novel strategies and drugs for curing and preventing the diseases are in high demand. Presently, researchers are now concentrating in targeting the disease pathogenesis by bioactive compounds from natural sources. This chapter details the various neurodegenerative disorders, their possible druggable targets, medicinal plants, and bioactive compounds effective for the treatment of neurodegenerative diseases and drugs in clinical trials.
摘要译文
在全球疾病负担和第二大主要死亡原因下，神经疾病在2015年的残疾-调整生命年（DALYs）子类别中被列为主要疾病。除神经系统疾病外，许多其他疾病也可能在晚期阶段导致神经退行性变。中枢神经系统中的这种神经元丢失导致了显着的功能障碍，并导致了慢性神经退行性疾病病理，例如阿尔茨海默氏病，帕金森氏病和全世界的多发性硬化症。迄今为止，已有许多药物可用于控制和治疗神经退行性疾病，但是目前其结果尚不令人满意。因此，迫切需要用于治疗和预防该疾病的新颖策略和药物。目前，研究人员现在正致力于通过天然来源的生物活性化合物靶向疾病的发病机理。本章详细介绍了各种神经退行性疾病，其可能的可治疗靶标，药用植物以及可在临床试验中有效治疗神经退行性疾病和药物的生物活性化合物。
Raj V. 1 ;J.R.Kumar 1 ;ChukwuebukaEgbuna 2 ;Jonathan C.Ifemeje 2 ;. Phytochemicals as therapeutic interventions in neurodegenerative diseases. Phytochemicals Lead Compounds New Drug Discovery[M].US: ELSEVIER, 2020: 161-178