摘要
Parkinson's disease is a progressive neurodegenerative disorder. Although both genetic and environmental factors are implicated in the development of Parkinson's disease, the cause of the disease is still unclear. So far conventional treatments to Parkinson's are symptomatic relief and focused mainly on motor symptoms. Chinese herbal medicine has been used to treat many conditions in China, Korea, Japan, and many Southeast Asian countries for 1000 years. During past a few decades, Chinese herbal medicine has gained wider and increasing acceptance within both public and medical profession due to its effectiveness on many conditions in western countries. In this chapter, mechanisms of action of many Chinese herbal compounds/extracts and Chinese herb formulas on the models of Parkinson's were reviewed. Further, reports of effectiveness of Chinese herb formulas on patients with Parkinson's were summarized. It was shown that both Chinese herbal compounds/extracts and herb formulas have either specific target mechanisms of action or multitargets mechanisms of action, as antioxidant, antiinflammatory, and antiapoptosis agents. Clinical studies showed that Chinese herb formulas as an adjunct improved both motor and nonmotor symptoms, and reduced dose of dopaminergic drugs and occurrence of dyskinesia. The evidence from the studies suggests that Chinese herb medicine has potential, acting as neuroprotective to slow down the progression of Parkinson’s, and it is able to simultaneously treat both motor and nonmotor symptoms of Parkinson’s. More studies are needed to explore the new compounds/extracts derived from Chinese herbs, in particular, their mechanisms of action. It is hopeful that new drugs developed from Chinese herb compounds/extracts and Chinese herb formulas will lead to better and complimentary therapy to PD.
摘要译文
帕金森氏病是一种进行性神经退行性疾病。尽管遗传和环境因素均与帕金森氏病的发展有关，但该病的病因仍不清楚。迄今为止，帕金森氏症的常规治疗是症状缓解，主要集中在运动症状上。在中国，韩国，日本和许多东南亚国家，中草药已被用于治疗许多疾病，已有1000多年的历史了。在过去的几十年中，由于中草药在西方国家的许多条件下都具有疗效，因此在公共和医学界得到了越来越广泛的接受。在本章中，回顾了许多中草药化合物/提取物和中草药配方对帕金森氏病模型的作用机理。此外，总结了中草药配方对帕金森氏病患者的疗效报告。结果表明，中草药化合物/提取物和草药配方均具有特定的靶作用机理或多靶作用机理，如抗氧化剂，抗炎剂和抗凋亡剂。临床研究表明，中草药配方可同时改善运动和非运动症状，并减少多巴胺能药物的剂量和运动障碍的发生。研究表明，中草药具有潜在的神经保护作用，可以减缓帕金森氏症的进展，并且能够同时治疗帕金森氏症的运动和非运动症状。需要更多的研究来探索源自中草药的新化合物/提取物，尤其是其作用机理。希望由中草药化合物/提取物和中草药配方开发的新药将导致更好和补充PD的疗法。
Chapter Three - Effect and Mechanism of Chinese Herbal Medicine on Parkinson's Disease. International Review of Neurobiology Volume 135[M].NL: ELSEVIER, 2017: 57-76