摘要
Platelet-rich plasma (PRP) is a versatile autologous blood product with regenerative, anti-inflammatory, and anti-microbial properties, derived from the growth factors and cytokines contained and released from platelets concentrated at supraphysiological levels. The basic science of PRP has demonstrated its regenerative and immunomodulatory properties via cell, tissue, and preclinical animal model studies, and clinical interest in translation of these properties has extended rapidly to regenerative medicine applications for musculoskeletal and spine disorders. However, randomized clinical trials of PRP therapy for osteoarthritis and chronic tendinopathy thus far have yielded often contradictory results. Therefore, efforts are underway to define both PRP composition and the underlying pathophysiology of specific disease processes, in order to elucidate the biological targets of PRP therapy and ultimately to improve clinical outcomes.
摘要译文
富含血小板的血浆（PRP）是一种具有再生，抗炎和抗微生物特性的多用途自体血液产品，源自于超生理水平浓缩的血小板所含和释放的生长因子和细胞因子。 PRP的基础科学已通过细胞，组织和临床前动物模型研究证明了其再生和免疫调节特性，并且对这些特性进行翻译的临床兴趣已迅速扩展至肌肉骨骼和脊柱疾病的再生医学应用。然而，迄今为止，针对骨关节炎和慢性肌腱病的PRP治疗的随机临床试验通常得出矛盾的结果。因此，正在努力定义PRP的组成和特定疾病过程的潜在病理生理学，以阐明PRP治疗的生物学目标并最终改善临床疗效。
Xiaoning (Jenny) Yuan.1;Alfred C. Gellhorn.2. Platelet-Rich Plasma. Regenerative Medicine for Spine and Joint Pain[M].DE: Springer, 2020: 55-86