摘要
Cationic host defence peptides (CHDP) are conserved peptide components of the innate immune system. These peptides, also known as antimicrobial peptides, were originally discovered and described on the basis of their direct microbicidal properties. However, it has become increasingly clear that CHDP, such as the human cathelicidin hCAP18/LL-37, have an extensive range of immunomodulatory properties that can be complementary to microbicidal activity or may even represent their major antimicrobial function. As a result of its capacity to interact with cells involved in host defence LL-37 can modulate both innate inflammatory processes and interact with the generation of adaptive immunity. CHDP have been implicated in a variety of disease processes at diverse organ sites and are attracting increasing attention as templates for the development of novel immunomodulatory antimicrobial therapeutics. This chapter will focus on the antimicrobial and immunomodulatory properties of hCAP18/LL-37 and the underlying mechanisms involved in the bioactivity of this peptide.
摘要译文
阳离子宿主防御肽（CHDP）是保守的先天免疫系统的肽组分。这些肽，也被称为抗微生物肽，最初发现及其直接杀菌性能的基础上描述。然而，它已成为越来越清楚，CHDP，如人抗菌肽hCAP18 / LL-37，具有免疫调节特性，可以互补的抗菌活性，甚至可以代表他们的主要抗菌功能的一个广泛的范围。作为它的容量的结果与参与宿主防御的LL-37的细胞相互作用可以调节先天炎性过程以及与获得性免疫的产生相互作用。CHDP已牵涉在多种疾病过程中的不同的器官部位和正吸引越来越多的关注，作为新型免疫调节抗微生物治疗学的发展模板。本章将重点hCAP18 / LL-37的抗菌和免疫调节性能以及参与这种肽的生物活性的基本机制。
Paula E. Beaumont (00041); Hsin-Ni Li (00041); Donald J. Davidson (00041). LL-37: An Immunomodulatory Antimicrobial Host Defence Peptide. Antimicrobial Peptides and Innate Immunity [M].DE: Springer, 2013: 97-121