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Claviceps purpurea (Ergot): Culture and Bioproduction of Ergot Alkaloids 收藏

Claviceps purpurea(Ergot):麦角生物碱的培养和生物生产
摘要
Ergot (Claviceps purpurea), best known as a disease of rye and some other grasses, is probably the most widely cultivated fungus and has now become an important field crop. The main reason for its importance is the presence of ergot alkaloids, extensively used in medicine. Currently, ergot alkaloids cover a large field of therapeutic uses as drugs of high potency in the treatment of uterine atonia, postpartum bleeding, migraine, orthostatic circulatory disturbances, senile cerebral insufficiency, hypertension, hyperprolactinemia, acromegaly, and parkinsonism (Berde and Schild 1978). Recently, new therapeutic uses have emerged, such as, e. g., against schizophrenia (Markstein et al. 1992), applications based on newly discovered antibacterial (Eich et al. 1985) and cytostatic effects (Eich at al. 1986), immunomodulatory (Šterzl et al. 1987) and hypolipemic activity (Golda et al. 1980; Cincotta and Meier 1989).
摘要译文
麦角(Claviceps purpurea),最广为人知的黑麦和其他草类疾病,可能是最广泛栽培的真菌,现在已成为重要的田间作物。其重要性的主要原因是麦角生物碱的存在,广泛用于医学中。目前,麦角生物碱在治疗子宫癌,产后出血,偏头痛,直立性循环障碍,老年性脑供血不足,高血压,高催乳素血症,肢端肥大症和帕金森病方面具有很高的治疗用途,涉及大范围的治疗用途(Berde和Schild 1978) 。最近,出现了新的治疗用途,例如e。 g。,针对精神分裂症(Markstein et al。 1992),基于新发现的抗菌剂的应用(Eich等。 1985)和细胞抑制效应(Eich at al。 1986),免疫调节(Šterzl等。 1987)和hypolipemic活动(Golda et al。 1980; Cincotta和Meier 1989)。
V. Křen[1];P. Harazim[2];Z. Malinka[2]. Claviceps purpurea (Ergot): Culture and Bioproduction of Ergot Alkaloids. Medicinal and Aromatic Plants VII[M].DE: Springer, 1994: 139-156