摘要
Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis are neurodegenerative disorders that are characterized by a progressive degeneration of nerve cells eventually leading to dementia. While these diseases affect different neuronal populations and present distinct clinical features, they share in common several features and signaling pathways. In particular, energy metabolism defects, oxidative stress, and excitotoxicity are commonly described and might be correlated with AMP-activated protein kinase (AMPK) deregulation. AMPK is a master energy sensor which was reported to be overactivated in the brain of patients affected by these neurodegenerative disorders. While the exact role played by AMPK in these diseases remains to be clearly established, several studies reported the implication of AMPK in various signaling pathways that are involved in these diseases’ progression. In this chapter, we review the current literature regarding the involvement of AMPK in the development of these diseases and discuss the common pathways involved.
摘要译文
阿尔茨海默病，帕金森病，亨廷顿病，肌萎缩性侧索硬化是神经变性疾病，其特征在于神经细胞的进行性退化，最终导致痴呆虽然这些疾病影响不同的神经元群体并呈现出不同的临床特征，但它们共同具有共同的几个特征和信号通路。特别地，能量代谢缺陷，氧化应激和兴奋性毒性通常被描述，并可能与AMP激活蛋白激酶（AMPK）去调节作用相关据报道，AMPK是一种主要的能量传感器，据报道在这些神经退行性疾病受影响的患者的大脑中过度活化虽然AMPK在这些疾病中发挥的确切作用尚待明确，几项研究报道了AMPK在涉及这些疾病的各种信号通路中的意义 - 进展在本章中，我们回顾了目前关于AMPK参与这些疾病发展的文献，并讨论了涉及的共同途径
Manon Domise1Valérie Vingtdeux1Email author. AMPK in Neurodegenerative Diseases. AMP-activated Protein Kinase[M].DE: Springer, 2016