图书章节

Production of Virus-Like Particles for Vaccination 收藏

用于疫苗接种的病毒颗粒的生产
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作者
Christine M. Thompson (3); (4); Marc G. Aucoin (5); Amine A. Kamen (4); (6);
作者单位
3. Department of Chemical Engineering, Ecole Polytechnique de Montreal, 2500, Chemin de Polytechnique, Montreal, QC, Canada 4. National Research Council Canada, Montreal, QC, Canada 5. Department of Chemical Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON, Canada, N2L 3G1 6. Department of Bioengineering, McGill University, Montreal, QC, Canada
关键词
Viral vector ;Virus-like particle ;VLP ;Baculovirus ;Insect cells
关键词译文
病毒载体;病毒样颗粒; VLP;杆状病毒;昆虫细胞
页码
299-315
DOI
10.1007/978-1-4939-3043-2_14
来源信息
Baculovirus and Insect Cell Expression Protocols ISBN：9781493930425, 2016年, 299-315页
摘要
The ability to make a large variety of virus-like particles (VLPs) has been successfully achieved in the baculovirus expression vector system (BEVS)/insect cell system. The production and scale-up of these particles, which are mostly sought as vaccine candidates, are currently being addressed. Furthermore, these VLPs are being investigated as delivery agents for use as therapeutics. The use of host insect cells allows mass production of VLPs in a proven scalable system.
摘要译文
在杆状病毒表达载体系统（BEVS）/昆虫细胞系统中已经成功实现了大量病毒样颗粒（VLPs）的生产和扩大。 ，目前正在被解决。此外，这些VLP正在被研究作为用作治疗剂的递送剂。使用宿主昆虫细胞允许在经验证的可扩展系统中批量生产VLP
Christine M. Thompson (3); (4); Marc G. Aucoin (5); Amine A. Kamen (4); (6);. Production of Virus-Like Particles for Vaccination. Baculovirus and Insect Cell Expression Protocols[M].DE: Springer, 2016: 299-315