摘要
Feed provision is one of the highest costs of beef production and improvement in efficiency has the potential to not only increase profits for cattle producers but to decrease the environmental footprint of beef cattle production. Residual feed intake (RFI) has increasingly become the measure of choice when evaluating feed efficiency in beef cattle especially because it is independent of growth and mature size. RFI is a prime candidate for marker assisted selection (MAS) as the trait is moderately heritable and is expensive to measure. The main objective of this work is to identify the genetic component of feed efficiency, measured as RFI, by identifying genetic marker associations and quantitative trait loci (QTL) throughout the bovine genome. This work was done using ∼2,600 markers on the 29 autosomes in 460 beef cattle. The first objective was to fine map QTL for RFI in beef cattle. In total, 24 QTL for RFI were identified. No QTL were identified on BTA 8, 10, 15, 16, 27. The most significant QTL for RFI was located on BTA 3 at 82 cM ( P = 7.60 x 10-5 ). A whole-genome association (WGA) study was also performed using the same SNPs and 150 were identified with P
摘要译文
进料供给是牛肉生产和提高效率的最高成本之一已经不仅增加利润养牛生产者，但降低肉牛生产对环境的影响的潜力。剩余采食量（RFI）评价肉牛饲料效率时，特别是因为它是独立的生长和成熟的规模已经越来越成为首选措施。RFI是标记辅助选择（MAS）的特点是适度遗传的，是昂贵的测量的主要候选人。这项工作的主要目的是确定的饲料效率的遗传成分，测定RFI，通过识别在整个牛基因组的遗传标记协会和数量性状位点（QTL）。做用~2,600上的标记29常染色体460肉牛这项工作。第一个目标是要罚款的地图为QTL在RFI肉牛。总体而言，24对QTL RFI进行鉴定。没有QTL鉴定上的BTA 8，10，15，16，27的最显著效QTL的RFI被位于BTA 3在82厘米（P = 7.60×10 -5）。还执行的全基因组关联（WGA）的研究使用相同的SNP和150被确定为P
Sherman, Esther Laura. The search for genetic markers and genes affecting feed efficiency in beef cattle[D]. CA: University of Alberta (Canada), 2009