摘要
Humans have been aware of diseases caused by baculoviruses for over 2000 years. The earliest historical accounts originated with descriptions of silkworm “jaundice,” a disease of Bombyx mori that we now know is caused by a nuclear polyhedrosis virus. In addition, people in various cultures throughout history have witnessed, without knowing their cause, spectacular epizootics and subsequent population declines brought about by nuclear polyhedrosis and granulosis viruses in caterpillars and sawfly larvae that feed in the forests and on field and vegetable crops (Benz, 1986). However, it was not until this century, and especially since the end of World War II, that the etiologic agents that cause these diseases were identified as a unique family of viruses, now known as the baculoviruses, which are largely restricted to insects. Moreover, although the literature from the first half of this century contains good descriptions of the diseases caused by nuclear polyhedrosis and granulosis viruses, it is only recently that we have begun to understand the progression of these diseases in their hosts and to identify the genes and gene products that underlie their various pathologies.
摘要译文
人类已经意识到杆状病毒造成的疾病超过2000年。最早的历史叙述起源于蚕的描述“黄疸，“我们现在知道的家蚕的一种疾病是由核型多角体病毒引起的。此外，历史上不同文化的人们在不知其原因的情况下，耳鼻喉科和随后的人口减少带来的核多角体病和颗粒体病毒在毛虫和锯虫幼虫，在森林和田间和蔬菜作物（奔驰，1986年）。然而，直到本世纪，特别是二战结束以来，导致这些疾病的病因才被确定为一个独特的病毒家族，现在被称为杆状病毒，主要限于昆虫。此外，尽管本世纪上半叶的文献对核型多角体病和颗粒体病毒引起的疾病有很好的描述，直到最近，我们才开始了解这些疾病在其宿主中的进展情况，并确定了构成其各种病状的基因和基因产物。
Brian A. Federici1. Baculovirus Pathogenesis. The Baculoviruses[M].DE: Springer, 1997: 33-59