摘要
Baculovirus multiplication culminates in high-level production of two temporally and morphologically distinct forms of infectious progeny (budded virus and occluded virus) in a process unique among animal viruses. Regulation of the 100 or more open reading frames required to accomplish productive infection is highly complex and involves sequential and coordinated expression of early, late, and very late genes. In the cascade of viral regulatory events, successive stages of virus replication are dependent on proper expression of genes within the preceding stage. Thus, critical to baculovirus replicative success is the appropriate expression and regulation of early genes. The products of early viral genes function to both accelerate replicative events and to prepare the host cell for virus multiplication, which represents an enormous tax on cellular biosynthetic capacity. Specific early genes are also essential for virus-mediated regulation of the host, including the control of larval molting and evasion of host antiviral responses such as apoptosis (see Chapters 10 and 11, this volume). Thus, early baculovirus genes collectively contribute to host range determination.
摘要译文
在动物病毒中独特的一个过程中，两个时间和形态上不同的传染性后代（芽殖病毒和闭塞病毒）的高水平生产高潮达到高潮。完成生产性感染所需的100个或更多开放阅读框的调控是非常复杂的，并涉及早期，晚期和非常晚期基因的连续和协调表达。在病毒调节事件的级联中，病毒复制的连续阶段依赖于前一阶段内基因的正确表达。从而，对杆状病毒复制成功至关重要的是早期基因的适当表达和调控。早期病毒基因的产物既能加速复制事件，又能使宿主细胞制备病毒繁殖，这代表了细胞生物合成能力的巨大税收。特定的早期基因也是病毒介导的宿主调节所必需的，包括控制幼虫蜕皮和逃避宿主抗病毒反应如细胞凋亡（参见本书第10章和第11章）。从而，早期的杆状病毒基因共同有助于宿主范围的确定。
Paul D. Friesen1. Regulation of Baculovirus Early Gene Expression. The Baculoviruses[M].DE: Springer, 1997: 141-170