摘要
Virus-like particles (VLPs) are formed by viral structural proteins that, when overexpressed, spontaneously self-assemble into particles that are antigenically indistinguishable from infectious virus or subviral particles. VLPs are appealing as vaccine candidates because their inherent properties (i.e., virus-sized, multimeric antigens, highly organised and repetitive structure, not infectious) are suitable for the induction of safe and efficient humoral and cellular immune responses. VLP-based vaccines have already been licensed for human and veterinary use, and many more vaccine candidates are currently in late stages of evaluation. Moreover, the development of VLPs as platforms for foreign antigen display has further broadened their potential applicability both as prophylactic and therapeutic vaccines. This chapter provides an overview on the design and use of VLPs for the development of new generation vaccines.
摘要译文
病毒样颗粒（VLP ）是由病毒结构蛋白，过表达时，自发地自组装成颗粒是从感染性病毒或亚病毒颗粒的抗原无法区别形成。VLP的呼吁作为候选疫苗，因为其固有的属性（即病毒大小，多聚抗原，高度组织化和重复结构，没有传染性）是适用于安全，高效的体液和细胞免疫应答的诱导。基于VLP的疫苗已经被许可用于人类和兽医用途，并有更多的候选疫苗目前在评估的后期阶段。此外， VLP的发展作为外来抗原的显示平台，进一步扩大了其潜在的应用既是预防性和治疗性疫苗。本章提供的VLP的新一代疫苗的研发设计和使用的概述。
Juan Bárcena (00211) Esther Blanco (00211). Design of Novel Vaccines Based on Virus-Like Particles or Chimeric Virions. Structure and Physics of Viruses An Integrated Textbook[M].DE: Springer, 2013: 631-665