摘要
Since the human appendix testis is a Mullerian duct derivative it has been theorised that rising oestrogen levels in puberty result in enlargement of this organ and consequent predisposition to torsion. This study sought to establish the presence or absence of both androgen and oestrogen receptors in the human appendix testis. Bilateral appendix testis specimens surgically excised from ten patients undergoing scrotal exploration for acute scrotum were stained immunohistochemically for androgen and oestrogen receptors. These were examined by light microscopy. The human appendix testis was found to express both oestrogen and androgen receptors. Marked regional variation of androgen and oestrogen receptor positivity was demonstrated. The surface epithelium and some stromal cells were androgen receptor positive, whereas oestrogen receptors were confined to ductular invaginations, gland-like structures and some stromal cells. Rising levels of androgens and oestrogens in pubertal boys may account for enlargement and the predisposition of the human appendix testis for torsion since this structure contains receptors for both.
摘要译文
因斯人类睾丸附件是一个苗勒管衍生物它有理论表明在青春期结果在此器官和随之而来的易感性扭转放大升起的雌激素水平。此研究的目的是建立在人类睾丸附件都雄激素和雌激素受体的存在或不存在。双侧睾丸附件标本10例接受阴囊探查急性阴囊手术切除了免疫组化染色雄激素和雌激素受体。这些由光显微镜检查。人类的睾丸附件发现表达雌激素和雄激素受体。雄激素和雌激素受体阳性明显的地区差异证明。表面上皮和某些基质细胞雄激素受体阳性，而雌激素受体仅限于胆管内陷，腺状结构和一些间质细胞。瑞星在青春期男孩雄激素水平和雌激素可能占扩大和人类睾丸附件扭转为的倾向，因为这种结构包含受体两种。
N. Samnakay [A1] R. J. Cohen [A2] J. Orford [A1] P. A. King [A1] R. J. Davies [A3]. Androgen and oestrogen receptor status of the human appendix testis[J]. Pediatric Surgery International, 2003,19(7): 520-524