摘要
Marine organisms provide an abundant source of potential medicines. Many of the marine-derived biomaterials have been shown to act as different mechanisms in immune responses, and in each case they can significantly control the immune system to produce effective reactions. Marine-derived proteins, peptides, and protein hydrolysates exhibit various physiologic functions, such as antimicrobial, anticancer, antioxidant, antihypertensive, and anti-inflammatory activities. Recently, the immunomodulatory properties of several antimicrobial peptides have been demonstrated. Some of these peptides directly kill bacteria and exhibit a variety of immunomodulatory activities that improve the host innate immune response and effectively eliminate infection. The properties of immunomodulatory proteins and peptides correlate with their amino acid composition, sequence, and length. Proteins and peptides with immunomodulatory properties have been tested in vitro and in vivo, and some of them have undergone different clinical and preclinical trials. This review provides a comprehensive overview of marine immunomodulatory proteins, peptides, and protein hydrolysates as well as their production, mechanisms of action, and applications in human therapy.
摘要译文
海洋生物提供了丰富的潜在药物来源。许多海洋衍生的生物材料已被证明在免疫应答中起到不同的机制，并且在每种情况下，它们可以显着控制免疫系统以产生有效反应。海洋衍生的蛋白质，肽和蛋白质水解产物表现出各种生理功能，例如抗微生物，抗癌，抗氧化剂，抗高血压和抗炎活动。最近，已经证明了几种抗微生物肽的免疫调节性质。这些肽中的一些直接杀死细菌并表现出各种免疫调节活动，可改善宿主先天免疫应答，有效地消除感染。免疫调节蛋白和肽的性质与它们的氨基酸组合物，序列和长度相关。已经在体外和体内测试了具有免疫调节性质的蛋白质和肽，其中一些经过不同的临床和临床前试验。本综述提供了海洋免疫调节蛋白，肽和蛋白质水解产物的全面概述以及它们的生产，作用机制和人类治疗的应用。
Hee Kyoung Kang[ 1;2]; Hyung Ho Lee[ 2]; Chang Ho Seo[ 2];Yoonkyung Park[ 1;3;[*]. Antimicrobial and Immunomodulatory Properties and Applications of Marine-Derived Proteins and Peptides[J]. Marine Drugs, 2019,17(6): 350