期刊文献

The Role of Oxidative Stress and Therapeutic Potential of Antioxidants in Graves’ Ophthalmopathy 收藏

抗氧化剂在坟墓眼科病变中的氧化应激和治疗潜力的作用

原文求助发布源

作者

Tzu-Yu Hou[ 1;2;3;4]; Shi-Bei Wu[ 5]; Hui-Chuan Kau[ 2;3;4;6] ;Chieh-Chih Tsai[ 2;3;4;*]

作者单位

[1] Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan [2] Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 11217, Taiwan [3] School of Medicine, National Yang Ming University, Taipei 11221, Taiwan [4] School of Medicine, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan [5] Biomedical Commercialization Center, Taipei Medical University, Taipei 11031, Taiwan [6] Department of Ophthalmology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 11259, Taiwan [*] Author to whom correspondence should be addressed. Academic Editor: Juan Gambini Biomedicines 2021, 9(12), 1871; https://doi.org/10.3390/biomedicines9121871

关键词

antioxidant; Graves’ disease; Graves’ ophthalmopathy; immune; oxidative stress; reactive oxygen species

关键词译文

抗氧化剂;格雷斯病;坟墓眼科病;免疫;氧化胁迫;反应性氧气

发布日期

10 December 2021

页码

1871

DOI

10.3390/biomedicines9121871

来源信息

Biomedicines ISSN：2227-9059, 2021年, 9卷, 12期, 1871页

摘要

Graves’ ophthalmopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease. It is characterized initially by an inflammatory process, followed by tissue remodeling and fibrosis, leading to proptosis, exposure keratopathy, ocular motility limitation, and compressive optic neuropathy. The pathogenic mechanism is complex and multifactorial. Accumulating evidence suggests the involvement of oxidative stress in the pathogenesis of GO. Cigarette smoking, a major risk factor for GO, has been shown to induce reactive oxygen species (ROS) generation and oxidative damage in GO orbital fibroblasts. In addition, an elevation in ROS and antioxidant enzymes is observed in tears, blood, and urine, as well as orbital fibroadipose tissues and fibroblasts from GO patients. In vitro and in vivo studies have examined the efficacy of various antioxidant supplements for GO. These findings suggest a therapeutic role of antioxidants in GO patients. This review summarizes the current understanding of oxidative stress in the pathogenesis and potential antioxidants for the treatment of GO.

摘要译文

Graves'眼科病变（GO）是Graves疾病最常见的脱滴表现形式。它最初是通过炎症过程的特征，其次是组织重塑和纤维化，导致馅目，暴露角病，眼睛运动限制和压缩视神经病变。致病机制是复杂的和多因素。积累证据表明氧化胁迫参与了去的发病机制。投影吸烟是对去的主要危险因素进行了一种重大的危险因素，以诱导Go眶纤维细胞中的活性氧物质（ROS）产生和氧化损伤。此外，在泪液，血液和尿液中观察到ROS和抗氧化酶的升高，以及来自患者的眶上纤维素组织和成纤维细胞。体外和体内研究已经检查了各种抗氧化剂补充剂的疗效。这些研究结果表明抗氧化剂在患者中的治疗作用。本综述总结了目前对发病机制和潜在抗氧化剂的氧化应激的理解。

Tzu-Yu Hou[ 1;2;3;4]; Shi-Bei Wu[ 5]; Hui-Chuan Kau[ 2;3;4;6] ;Chieh-Chih Tsai[ 2;3;4;*]. The Role of Oxidative Stress and Therapeutic Potential of Antioxidants in Graves’ Ophthalmopathy[J]. Biomedicines, 2021,9(12): 1871