摘要
Both obesity and aging are associated with the development of metabolic diseases such as type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose tissue is one of the mechanisms implicated in the progression of these diseases. Obesity and aging trigger adipose tissue alterations that ultimately lead to a pro-inflammatory phenotype of the adipose tissue-resident immune cells. Obesity and aging also share other features such as a higher visceral vs. subcutaneous adipose tissue ratio and a decreased lifespan. Here, we review the common characteristics of obesity and aging and the alterations in white adipose tissue and resident immune cells. We focus on the adipose tissue metabolic derangements in obesity and aging such as inflammation and adipose tissue remodeling.
摘要译文
肥胖症和老龄化既与2型糖尿病和心血管疾病等代谢疾病的发展有关。脂肪组织的慢性低级炎症是涉及这些疾病进展的机制之一。肥胖和老化触发器脂肪组织改变最终导致脂肪组织居民植物免疫细胞的促炎表型。肥胖和老龄化也分享其他功能，例如更高的内脏与皮下脂肪脂肪组织比和减少的寿命。在这里，我们审查了肥胖症和老化的常见特征以及白色脂肪组织和常规免疫细胞的改变。我们专注于肥胖和老化的脂肪组织代谢紊乱，例如炎症和脂肪组织重塑。
Marjorie Reyes-Farias[a][b];Julia Fos-Domenech[b];Dolors Serra[b][c];Laura Herrero[b][c];David Sánchez-Infantes[a][c][d]. White adipose tissue dysfunction in obesity and aging[J]. Biochemical Pharmacology, 2021,192