期刊文献

Stereotactic radiation treatment of a pituitary mass in a rabbit (Oryctolagus cuniculus) 收藏

立体定向辐射处理兔（oryctolagus cuniculus）的垂体质量

原文求助发布源

作者

Paula RodriguezDVM[a];David Sanchez-Migallon GuzmanLV; MS[b];Jessica RobertsonDVM[c];Alexandra D. La PorteDVM[a];Michelle G. HawkinsVMD[b];Joanne R. Paul-MurphyDVM[b];Katherine S. HansenDVM[b]

作者单位

[a]aThe William T. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USAaThe William T. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USA[b]bDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USAbDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USA[c]cDepartment of Zoological Medicine and Surgery, Los Angeles, CA, USAcDepartment of Zoological Medicine and Surgery, Los Angeles, CA, USA

关键词

Oryctolagus cuniculus;Rabbit;Pituitary tumor;Stereotactic radiation therapy;

关键词译文

Oryctolagus cuniculus;兔子；垂体肿瘤；立体定向辐射疗法；

发布日期

1 June 2022

页码

1-5

DOI

10.1053/j.jepm.2022.03.004

来源信息

Journal of Exotic Pet Medicine ISSN：1557-5063, 2022年, 42卷, 1-5页

摘要

A 9-year-old female spayed Holland Lop rabbit (Oryctolagus cuniculus) presented with abnormal eyelid positioning on the right eye of 2 week duration. A full neurological examination revealed ptosis, enopthalmia, decreased palpebral reflex of the right eye. A pre and post contrast CT-study confirmed a large heterogeneously contrast-enhancing and partially peripherally mineralized parasellar pituitary mass. Stereotactic radiation was performed delivering 3 fractions of 8 Gy every other day (total dose 24 Gy) using volumetric-modulated arc therapy for the pituitary mass. A progressive decrease in size of the pituitary mass was observed on two follow-up CT-studies at six- and eighteen-months post-radiotherapy. The adrenal panels performed during follow-up visits suggested increased adrenal activity post-radiotherapy. No adverse effects of radiation therapy were noted at home or subsequent veterinary visits. CT imaging was a reliable modality for diagnosing and monitoringthe pituitary mass. Treatment with stereotactic radiotherapy resulted in a marked reduction in the pituitary mass volume with a long survival time and without adverse effects. Radiation therapy should be considered a treatment option in rabbits with pituitary tumors and the protocol used in this case could be used as a reference for future cases.

摘要译文

一名9岁的雌性Spay荷兰Lop Rabbit（Oryctolagus cuniculus）在2周持续时间的右眼上表现出异常的眼睑位置。全面的神经系统检查表明ptosis，递减，右眼的骨反射降低。对比前后，CT研究证实了较大的异质对比度增强和部分外周矿化的parasellar垂体质量。立体定向辐射使用垂体质量的体积调节弧治疗每隔一天提供3个GY的3个分数（总剂量24 Gy）。在六分之十和十八个月后，垂体肿块的大小逐渐减小，在六个月后接受放射治疗。在随访期间进行的肾上腺面板表明，肾上腺疗法后肾上腺活性增加。在家或随后的兽医就诊时，没有发现放射治疗的不良影响。 CT成像是诊断和监测垂体质量的可靠方式。立体定向放射疗法的治疗导致垂体质量体积显着减少，生存时间长，没有不良反应。放射疗法应视为垂体肿瘤兔子的治疗选择，在这种情况下使用的方案可以用作将来病例的参考。

Paula RodriguezDVM[a];David Sanchez-Migallon GuzmanLV; MS[b];Jessica RobertsonDVM[c];Alexandra D. La PorteDVM[a];Michelle G. HawkinsVMD[b];Joanne R. Paul-MurphyDVM[b];Katherine S. HansenDVM[b]. Stereotactic radiation treatment of a pituitary mass in a rabbit (Oryctolagus cuniculus)[J]. Journal of Exotic Pet Medicine, 2022,42: 1-5