摘要
The short-chain fatty acids (SCFAs) propionate and butyrate—both products of gut microbiota-driven fermentation of soluble dietary fibre—activate intestinal gluconeogenesis via two distinct mechanisms in mice. European investigators showed that butyrate acts on intestinal gluconeogenesis gene expression through a cAMP-dependent pathway. By contrast, propionate mediated its beneficial metabolic effects by activating the expression of intestinal gluconeogenesis genes through a gut–brain neural circuit. The study suggests that intestinal gluconeogenesis is a causal link for the benefits of dietary fibre on energy and glucose homeostasis
摘要译文
短链脂肪酸（SCFA）丙酸酯和丁酸酯 - 肠道微生物植物驱动的肠道饮食纤维活化肠道葡萄糖发生的两种产品，通过两只小鼠的两种不同机制。欧洲调查人员显示丁酸盐通过营养依赖途径对肠糖生成基因表达作用。相比之下，丙酸酯通过通过肠脑神经回路激活肠葡糖生成基因的表达来介导其有益的代谢效果。该研究表明，肠道葡糖生成是膳食纤维对能量和葡萄糖稳态的益处的因果关系
Short-chain fatty acids regulate intestinal gluconeogenesis[J]. Nature Reviews Endocrinology, 2014,10(4)