期刊文献

DNA damage induced neuroinflammation in neurodegenerative disease 收藏

DNA损伤诱导神经退行性疾病中的神经炎炎症
原文求助 发布源
作者
Xuan Song[1];Theeng Mei AW[2];Fulin Ma[1];Danny Leung[2];Karl Herrup[3]
作者单位
[1]University of Pittsburgh Pittsburgh PA USA;[2]Hong Kong University of Science and Technology Hong Kong China;[3]Alzheimer Disease Research Center University of Pittsburgh Pittsburgh PA United States
发布日期
07 December 2020
DOI
10.1002/alz.047445
来源信息
Alzheimer's & Dementia ISSN：1552-5260, 2020年, 16卷, Sup3期
摘要
The neurological symptom is highly related to the activation of innate immune system in the brain in neurodegenerative disease. The robust activation of microglia, which includes an overproduction of cytokines, creates a pro-inflammatory environment that greatly contributes to the neuronal cell damage.
摘要译文
神经系统症状与神经变性疾病中脑内先天免疫系统的激活高度相关。微胶质细胞的鲁棒激活，包括过量的细胞因子，产生促炎环境，极大地有助于神经元细胞损伤。
Xuan Song[1];Theeng Mei AW[2];Fulin Ma[1];Danny Leung[2];Karl Herrup[3]. DNA damage induced neuroinflammation in neurodegenerative disease[J]. Alzheimer's & Dementia, 2020,16(Sup3)