期刊文献

MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization 收藏

Maia，FC受体类似3，在人体受精过程中取代Juno作为Izumo1受体

原文求助发布源

作者

Jana Vondrakova;Michaela Frolikova;Lukas Ded;Jiri Cerny;Pavla Postlerova;Veronika Palenikova;Ondrej Simonik;Zuzana Nahacka;Krystof Basus;Eliska Valaskova;Radek Machan;Allan Pacey;Zuzana Holubcova;Pavel Koubek;Zuzana Ezrova;Soojin Park;Ruiwu Liu;Raghavendran Partha;Nathan Clark;Jiri Neuzil;Masahito Ikawa;Kent Erickson;Kit S. Lam;Harry Moore;Katerina Komrskova

作者单位

Jana Vondrakova† https://orcid.org/0000-0003-3994-348XLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.Roles: Investigation, Methodology, and Writing - review & editing.View all articles by this authorMichaela Frolikova† https://orcid.org/0000-0002-9834-8405Laboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.Roles: Data curation, Investigation, Validation, Visualization, and Writing - review & editing.View all articles by this authorLukas Ded https://orcid.org/0000-0003-1053-4025Laboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.Roles: Conceptualization, Data curation, Formal analysis, Methodology, Software, and Visualization.View all articles by this author

发布日期

7 Sep 2022

DOI

10.1126/sciadv.abn0047

来源信息

Science advances ISSN：2375-2548, 2022年, 8卷, 36期

摘要

Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor–like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.

摘要译文

配子融合是哺乳动物施肥的关键事件。一个随机的单珠单晶体组合肽库代表合成的人卵模仿，并确定了先前未识别的配体为FC受体3，名为Maia，以与Juno交织在一起的神话女神。这种免疫球蛋白超级家族受体在人类的卵子上表达，并在精子 - 蛋的粘附和融合中发挥了重要作用。Maia与已知的Izumo1/Juno Sperm-Egg复合物形成了高度稳定的相互作用，允许特定的配子融合。MAIA同种型的复杂性可能会提供一种隐秘的性选择机制，以避免遗传不相容性并实现有利的健身结果。