期刊文献

NRF2 in Viral Infection 收藏

病毒感染的NRF2

原文求助发布源

作者

Angela Herengt;Jacob Thyrsted;Christian K. Holm

作者单位

Aarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark [*] Author to whom correspondence should be addressed. Academic Editor: Sander Bekeschus Antioxidants 2021, 10(9), 1491; https://doi.org/10.3390/antiox10091491

关键词

NRF2; virus; immunology

关键词译文

NRF2;病毒;免疫学

发布日期

2021-09-18

页码

1491

DOI

10.3390/antiox10091491

来源信息

Antioxidants ISSN：2076-3921, 2021年, 10卷, 9期, 1491页

摘要

The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emerging as an important factor in antiviral immunity through interferon-independent mechanisms. In the review, we give an overview of the scientific progress on the involvement and importance of NRF2 in the context of viral infection.

摘要译文

转录因子NRF2是动物细胞中氧化还原稳态的中心，是许多类型的癌症中的众所周知的化学驾驶员。最近，新的角色已经归因于NRF2，包括调节抗病毒干扰素反应和炎症。此外，NRF2是通过干扰素无关的机制作为抗病毒免疫的重要因素。在审查中，我们概述了NRF2在病毒感染情况下对NRF2的参与和重要性的研究进展。

Angela Herengt;Jacob Thyrsted;Christian K. Holm. NRF2 in Viral Infection[J]. Antioxidants, 2021,10(9): 1491