摘要
Autism spectrum disorder (ASD) is a serious multifactorial neurodevelopmental disorder often accompanied by strained social communication, repetitive behaviour, immune dysregulation, and gastrointestinal (GI) issues. Recent studies have recorded a link between dysbiosis in the gut microbiota (gm) and the primary stages of ASD. A bidirectional connection (also called microbiota-gut-brain-axis) exchanges information between the gut bacteria and central nervous system. When the homeostasis of the microenvironment of the gut is dysregulated, it causes oxidative stress, affecting neuronal cells and neurotransmitters, thereby causing neurodevelopmental disorders. Studies have confirmed a difference in the constitution of gut bacteria among ASD cases and their controls. Numerous studies on animal models of ASD have shown altered gm and its association with abnormal metabolite profile and altered behaviour phenotype. This process happens due to an abnormal metabolite production in gm, leading to changes in the immune system, especially in ASD. Hence, this review aims to question the current knowledge on gm dysbiosis and its related GI discomforts and ASD behavioural symptoms and shed light on the possible therapeutic approaches available to deal with this situation. Thereby, though it is understood that more research might be needed to prove an association or causal relationship between gm and ASD, therapy with the microbiome may also be considered as an effective strategy to combat this issue.
摘要译文
自闭症谱系障碍（ASD）是一种严重的多因素神经发育障碍，通常伴有紧张的社会沟通，重复行为，免疫失调和胃肠道（GI）问题。最近的研究已经记录了肠道微生物肿瘤（GM）和ASD的主要阶段之间的困难之间的联系。双向连接（也称为Microbiota-Gut-Brain-Axis）在肠道细菌和中枢神经系统之间交换信息。当肠道微环境的稳态失调时，它会导致氧化应激，影响神经元细胞和神经递质，从而导致神经发育障碍。研究证实了ASD病例肠道细菌构成的差异及其对照。众多关于ASD动物模型的研究表明，改变的GM及其与异常代谢物型材的关系和改变的行为表型。这一过程因转基因异常产生的代谢产量异常，导致免疫系统的变化，特别是在ASD中。因此，本综述旨在质疑目前关于转基因脱泻病的知识及其相关的GI不适和ASD行为症状，以及可用于处理这种情况的可能的治疗方法。因此，尽管据了解，可能需要更多的研究来证明GM和ASD之间的关联或因果关系，但与微生物组的治疗也可能被认为是打击这个问题的有效策略。
Balachandar Vellingiri[a];S.Y. Aishwarya[b][1];S. Benita Jancy[b][1];G. Sriram Abhishek[b][1];Harysh winster Suresh babu[a][c];Padmavathi Vijayakumar[a];Arul Narayanasamy[c];Sujitha Mariappan[b];R. Sangeetha[d];Abilash Valsala Gopalakrishnan[e];Ramakrishnan Parthasarathi[f];Mahalaxmi Iyer[g]. An anxious relationship between Autism Spectrum Disorder and Gut Microbiota: A tangled chemistry?[J]. Journal of Clinical Neuroscience, 2022,99: 169-189