摘要
Chinese herbal medicines (CHM) have been used to cure diseases for thousands of years. However, the bioactive ingredients of CHM are complex, and some CHM natural products cannot be directly absorbed by humans and animals. Moreover, the contents of most bioactive ingredients in CHM are low, and some natural products are toxic to humans and animals. Fermentation of CHM could enhance CHM bioactivities and decrease the potential toxicities. The compositions and functions of the microorganisms play essential roles in CHM fermentation, which can affect the fermentation metabolites and pharmaceutical activities of the final fermentation products. During CHM fermentation, probiotics not only increase the contents of bioactive natural products, but also are beneficial for the host gut microbiota and immune system. This review summarizes the advantages of fermentation of CHM using probiotics, fermentation techniques, probiotic strains, and future development for CHM fermentation. Cutting-edge microbiome and synthetic biology tools would harness microbial cell factories to produce large amounts of bioactive natural products derived from CHM with low-cost, which would help speed up modern CHM biomanufacturing.
摘要译文
中草药（CHM）已被用来治愈数千年。但是，CHM的生物活性成分很复杂，某些CHM天然产物不能直接被人类和动物吸收。此外，CHM中大多数生物活性成分的含量很低，一些天然产品对人类和动物有毒。CHM的发酵可以增强CHM生物活性并降低潜在的毒性。微生物的组成和功能在CHM发酵中起着至关重要的作用，这可能会影响最终发酵产品的发酵代谢产物和药物活性。在CHM发酵过程中，益生菌不仅增加了生物活性天然产物的含量，而且对宿主肠道菌群和免疫系统也有益。这篇综述总结了使用益生菌，发酵技术，益生菌菌株以及CHM发酵的未来开发的CHM发酵优势。尖端的微生物组和合成生物学工具将利用微生物细胞工厂生产大量具有低成本CHM的生物活性天然产品，这将有助于加快现代CHM生物制造。
Xiaoling Zhang[1];Qin Miao[1];Chengxue Pan[1];Jia Yin[2];Leli Wang[2];Lingbo Qu[3];Yulong Yin[4];Yongjun Wei[1]. Research advances in probiotic fermentation of Chinese herbal medicines[J]. iMeta, 2023,2(2)