期刊文献

Methanol leaf extract of Paullinia pinnata exerts sleep-enhancing and anticonvulsant effects via a mechanism involving the GABAergic pathway 收藏

Paullinia pinnata的甲醇叶提取物通过涉及GABA能途径的机制发挥睡眠增强和抗惊厥作用
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作者
Muideen A. Ajibade[a];Abigail M. Akhigbemen[a];Ngozi P. Okolie[b];Raymond I. Ozolua[a][1]
作者单位
[a]Department of Pharmacology & Toxicology, Faculty of Pharmacy, University of Benin, Benin City 300001, NigeriaDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, University of Benin, Benin City 300001, Nigeria[b]Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City 300001, NigeriaDepartment of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City 300001, Nigeria[1]1ORCID iD: 0000-0003-1257-6325
关键词
Sleep;Convulsion;Glutamic acid decarboxylase;Antioxidants;
关键词译文
睡眠；抽搐；谷氨酸脱羧酶；抗氧化剂；
发布日期
1 July 2022
DOI
10.1016/j.eplepsyres.2022.106943
来源信息
Epilepsy Research ISSN：0920-1211, 2022年, 183卷
摘要
PurposeLeaf extracts of Paullinia pinnata L. (Sapindaceae) are used in ethnomedicine for the treatment of central nervous system-related diseases such as insomnia and epilepsy. We determined the bioactive constituents, sleep-enhancing and anti-convulsant potentials, and possible mechanisms of action of P. pinnata methanol leaf extract (PPME).
摘要译文
Paullinia pinnata L.（sapindaceae）的紫罗林提取物用于民族医学中的中枢神经系统相关疾病，例如失眠和癫痫。我们确定了生物活性成分，睡眠增强和抗惊厥电位，以及P. pinnata甲醇叶提取物（PPME）的可能作用机理。
Muideen A. Ajibade[a];Abigail M. Akhigbemen[a];Ngozi P. Okolie[b];Raymond I. Ozolua[a][1]. Methanol leaf extract of Paullinia pinnata exerts sleep-enhancing and anticonvulsant effects via a mechanism involving the GABAergic pathway[J]. Epilepsy Research, 2022,183