摘要
ObjectivesAutism spectrum disorder (ASD) is a neurodevelopmental disorder that often occurs in children and seriously affects daily life. In recent years, many studies have shown that intestinal microbial imbalance and intestinal-brain dysfunction may be the critical mechanism for the formation of ASD. This article reviews the changes in the gut microbiota of patients and their impact mechanisms, and the current mechanisms of probiotic and traditional Chinese medicine therapies.MethodsA review of contemporary peer-reviewed studies. Pubmed and Cnki were the databases used to identify the studies.ResultsThe majority of the reviewed studies demonstrated that changes in the gut microbiota can directly or indirectly induce ASD by affecting the immune system, nervous system, and endocrine system. Probiotics can improve brain function by affecting the vagus nerve, and improve metabolism by regulating the expression of neuroendocrine hormones. According to the Chinese medicine theory, there are three leading causes of ASD such as deficiency of kidney essence, stagnation of liver qi, and malnutrition of heart spirit.ConclusionsThe fermentation of Chinese herbal medicine and probiotics can be further studied and may become a new type of treatment for ASD in the future.
摘要译文
Objectivesautism谱系障碍（ASD）是一种神经发育障碍，经常发生在儿童中，并严重影响日常生活。近年来，许多研究表明，肠道微生物失衡和肠脑功能障碍可能是ASD形成的关键机制。本文回顾了患者肠道菌群及其影响机制的变化，以及益生菌和中药疗法的当前机制。当代同行评审研究的方法评论。 PubMed和CNKI是用于识别研究的数据库。重新审查的研究表明，肠道微生物群的变化可以直接或间接地通过影响免疫系统，神经系统和内分泌系统来直接或间接诱导ASD。益生菌可以通过影响迷走神经来改善大脑功能，并通过调节神经内分泌激素的表达来改善新陈代谢。根据中医理论，有三个主要原因是ASD的三个主要原因，例如肾脏本质缺乏，肝Qi的停滞和心脏精神营养不良。结论中，可以进一步研究中草药和益生菌的发酵，并可能成为一种新类型未来对ASD的治疗。
Li; Zhixun[1];Liao; Yuyao[1];Zhou; Qing[2];Qu; Qingsong[1];Sheng; Mengke[1];Lv; Lijing[1];Yang; Jiaqi[1];Shi; Yanshuang[1];Shi; Xinyuan[1]. Changes of Gut Microbiota in Autism Spectrum Disorders and Common Probiotics & Chinese Herbal Medicine Therapeutic Mechanisms: a Review[J]. Advances in Neurodevelopmental Disorders, 2022,6(3): 290-303