摘要
In this review, an attempt was made to substantiate the possibility for neurotrophins to be involved in the development of immune tolerance based on data accumulated on neurotrophin content and receptor expression in the trophoblast and immune cells, in particular, in natural killer cells. Numerous research results are reviewed to show that the expression and localization of neurotrophins along with their high-affinity tyrosine kinase receptors and low-affinity p75NTR receptor in the mother-placenta-fetus system indicate the important role of neurotrophins as binding molecules in regulating the crosstalk between the nervous, endocrine, and immune systems in pregnancy. An imbalance between these systems can occur with tumor growth and pathological processes observed in pregnancy complications and fetal development anomalies.
摘要译文
在这篇综述中，试图证实神经营养蛋白与基于神经营养蛋白含量积累的数据和受体表达在滋养细胞和免疫细胞中，尤其是在天然杀伤细胞中累积的数据有关。审查了许多研究结果，以表明神经营养蛋白的表达和定位以及其高亲和力酪氨酸激酶受体和低亲和力的p75NTR受体在母叶丙烷 - fetus系统中表明神经营养蛋白作为结合分子在调节Crosstalk中的重要作用在怀孕的神经，内分泌和免疫系统之间。这些系统之间的不平衡可能发生在肿瘤的生长和妊娠并发症和胎儿发育异常中观察到的病理过程。
Yulia P. Milyutina[1];Alexander V. Arutjunyan[1];Andrey V. Korenevsky[1];Sergey A. Selkov[1];Igor Yu. Kogan[1]. Neurotrophins: are they involved in immune tolerance in pregnancy?[J]. American Journal of Reproductive Immunology, 2023,89(4)