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Kaempferol and Kaempferol Rhamnosides with Depigmenting and Anti-Inflammatory Properties 收藏

Kaempferol和Kaempferol rhamnosides，具有甲状腺和抗炎性质

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作者

Ho Sik Rho[ 1;[*]; Amal Kumar Ghimeray[ 2]; Dae Sung Yoo[ 2]; Soo Mi Ahn[ 3]; Sun Sang Kwon[ 4]; Keun Ha Lee[ 4]; Dong Ha Cho[ 2];Jae Youl Cho[ 5;[*]

作者单位

[1] R & D Center, AmorePacific Corporation, Yongin, Korea [2] College of Biomedical Science, Kangwon National University, Chuncheon, Korea [3] Skin Biotechnology Center, Kyung Hee University, Suwon, Korea [4] R & D Center, Morechem Corporation, Seoul, Korea [5] Department of Genetic Engineering, Sungkyunkwan University, Suwon, Korea [*] Authors to whom correspondence should be addressed. Molecules 2011, 16(4), 3338-3344; https://doi.org/10.3390/molecules16043338

关键词

kaempferol; rhamnoside; depigmentation; anti-inflammation

关键词译文

kaempferol;犀牛;脱象;抗炎

发布日期

2011-04-18

页码

3338

DOI

10.3390/molecules16043338

来源信息

Molecules Online ISSN：1420-3049, 2011年, 16卷, 4期, 3338页

摘要

The objective of this study was to examine the biological activity of kaempferol and its rhamnosides. We isolated kaempferol (1), a-rhamnoisorobin (2), afzelin (3), and kaempferitrin (4) as pure compounds by far-infrared (FIR) irradiation of kenaf (Hibiscus cannabinus L.) leaves. The depigmenting and anti-inflammatory activity of the compounds was evaluated by analyzing their structure-activity relationships. The order of the inhibitory activity with regard to depigmentation and nitric oxide (NO) production was kaempferol (1) > a-rhamnoisorobin (2) > afzelin (3) > kaempferitrin (4). However, a-rhamnoisorobin (2) was more potent than kaempferol (1) in NF-kB-mediated luciferase assays. From these results, we conclude that the 3-hydroxyl group of kaempferol is an important pharmacophore and that additional rhamnose moieties affect the biological activity negatively.

摘要译文

本研究的目的是检查Kaempferol及其犀牛的生物活性。我们孤立的Kaempferol，A-rhamoisorobin（2），Afzelin（3）和Kaempferitrin（4）作为乳面（芙蓉Cancabinus L.）叶的远红外（FIR）照射。通过分析它们的结构 - 活性关系来评估化合物的脱粒和抗炎活性。关于脱敏和一氧化氮（NO）产生的抑制活性的顺序是kaempferol，A-rhamnoisorobin（2）> afzelin（3）> kaempferitrin（4）。然而，在NF-KB介导的荧光素酶测定中，A-rhamoisorobin（2）比kaempferol（1）更有效。从这些结果来看，我们得出结论，Kaempferol的3-羟基是一个重要的药镜，并且额外的鼠李糖部分产生负面影响。

Ho Sik Rho[ 1;[*]; Amal Kumar Ghimeray[ 2]; Dae Sung Yoo[ 2]; Soo Mi Ahn[ 3]; Sun Sang Kwon[ 4]; Keun Ha Lee[ 4]; Dong Ha Cho[ 2];Jae Youl Cho[ 5;[*]. Kaempferol and Kaempferol Rhamnosides with Depigmenting and Anti-Inflammatory Properties[J]. Molecules Online, 2011,16(4): 3338