摘要
Reactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death. Many common pathological processes, including various cancer types and neurodegenerative diseases, are inflammation and oxidative stress triggers, or even initiate them. Keap1-Nrf2 is a master antioxidant pathway in cytoprotective mechanisms through Nrf2 target gene expression. Activation of the Nfr2 pathway benefits cells in the early stages and reduces the level of ROS. In contrast, hyperactivation of Keap1-Nrf2 creates a context that supports the survival of both healthy and cancerous cells, defending them against oxidative stress, chemotherapeutic drugs, and radiotherapy. Considering the dual role of Nrf2 in suppressing or expanding cancer cells, determining its inhibitory/stimulatory position and targeting can represent an impressive role in cancer treatment. This review focused on Nrf2 modulators and their roles in sensitizing breast cancer cells to chemo/radiotherapy agents.
摘要译文
鉴定出活性氧（ROS）以控制与细胞增殖，凋亡和分化有关的各种基本信号中间体的表达和活性。确实，Ros代表了支撑细胞存活和死亡的双刃剑。许多常见的病理过程，包括各种癌症类型和神经退行性疾病，都是炎症和氧化应激触发因素，甚至引发它们。 KEAP1-NRF2是通过NRF2靶基因表达的细胞保护机理中的主要抗氧化剂途径。 NFR2途径的激活在早期阶段使细胞受益，并降低ROS的水平。相反，KEAP1-NRF2的过度激活创造了一种支持健康和癌细胞生存的环境，捍卫它们免受氧化应激，化学治疗药物和放射疗法的影响。考虑到NRF2在抑制或扩展癌细胞中的双重作用，确定其抑制/刺激位置和靶向可以代表癌症治疗中的令人印象深刻的作用。这篇综述的重点是NRF2调节剂及其在使乳腺癌细胞对化学/放射治疗剂敏感的作用中。
Somayyeh Ghareghomi;Mehran Habibi-Rezaei;Marzia Arese;Luciano Saso;Ali Akbar Moosavi-Movahedi. Nrf2 Modulation in Breast Cancer[J]. Biomedicines, 2022,10(10): 2668