摘要
Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial activities against infectious bacteria, viruses, and fungi. Increasing evidence suggests that HDPs can also indirectly protect hosts by modulating their immune responses. Due to these dual roles, HDPs have been considered one of the most promising antibiotic substitutes to improve growth performance, intestinal health, and immunity in farm animals. This review describes the antimicrobial and immunomodulatory roles of host defense peptides and their recent applications in animal production.
摘要译文
宿主防御肽（HDP）是针对传染性细菌，病毒和真菌的宽光谱抗菌活性的小分子。越来越多的证据表明，HDP还可以通过调节其免疫反应来间接保护宿主。由于这些双重作用，HDP被认为是提高农场动物生长性能，肠道健康和免疫力的最有希望的抗生素替代品之一。这篇综述描述了宿主防御肽的抗菌和免疫调节作用及其在动物生产中的最新应用。
Wu; Di[1];Fu; Linglong[1];Wen; Weizhang[1];Dong; Na[1]. The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production[J]. Journal of Animal Science and Biotechnology, 2022,13(1): 1-14