摘要
The intestinal microflora is a large bacterial community that colonizes the gut, with a metabolic activity equal to an organ and various functions that affect the physiology and pathology of the host's mucosal immune system. Intestinal bacteria are useful in promotion of human health, but certain components of microflora, in genetically susceptible individuals, contribute to various pathological disorders, including inflammatory bowel disease. Clinical and experimental observations indicate an imbalance in protective and harmful microflora components in these disorders. Manipulation of gut flora to enhance its protective and beneficial role represents a promising field of new therapeutic strategies of inflammatory bowel disease. In this review, we discuss the implication of gut flora in the intestinal inflammation that justifies the role of probiotics and prebiotics in the prevention and treatment of inflammatory bowel disease and we address the evidence for therapeutic benefits from their use in experimental models of colitis and clinical trials.
摘要译文
肠道菌群是一个大的细菌群落的殖民肠道，具有代谢活性等于器官以及影响宿主的粘膜免疫系统的生理和病理的各种功能。肠道细菌是在促进人体健康有益的，但微生物的某些部件，在遗传上易感的个体，向各种病理病症，包括炎症性肠病。临床和实验观察表明在这些疾病保护性和有害菌群的组件的不平衡。肠道菌群的操纵，以加强它的保护和有益的作用表示的炎症性肠病的新的治疗策略一个有前途的领域。在这次审查中，s和炎性肠疾病的预防和治疗的益生元，我们地址为从它们在结肠炎和临床试验的实验模型中使用的治疗益处的证据。
Dimitrios Damaskos and George Kolios[*]. Probiotics and prebiotics in inflammatory bowel disease: microflora ‘on the scope’[J]. British Journal of Clinical Pharmacology, 2008,65(4): 453-467