摘要
Vaccination is an efficient way to prevent the occurrence of many infectious diseases in humans. To date, several viral vectors have been utilized for the generation of vaccines. Among them, baculovirus—categorized as a nonhuman viral vector—has been used in wider applications. Its versatile features, like large cloning capacity, nonreplicative nature in mammalian cells, and broad tissue tropism, hold it at an excellent position among vaccine vectors. In addition to ease and safety during swift production, recent key improvements to existing baculovirus vectors (such as inclusion of hybrid promoters, immunostimulatory elements, etc.) have led to significant improvements in immunogenicity and efficacy of surface-displayed antigens. Furthermore, some promising preclinical results have been reported that mirror the scope and practicality of baculovirus as a vaccine vector for human applications in the near future. Herein, this review provides an overview of the induced immune responses by baculovirus surface-displayed vaccines against influenza and other infectious diseases in animal models, and highlights the strategies applied to enhance the protective immune responses against the displayed antigens.
摘要译文
疫苗接种是一种有效的方法，可以防止人类许多传染病的发生。迄今为止，已经利用了几种病毒载体来产生疫苗。其中，杆状病毒被分类为非人类病毒载体 - 已用于更广泛的应用中。与大型克隆能力一样，哺乳动物细胞中的不良性，以及宽组织的覆身性质，将其保持在疫苗载体的优异位置。除了在SWIFT生产过程中的缓解和安全性外，最近对现有杆状病毒载体的关键改善（例如包含杂交启动子，免疫刺激元件等）的关键改善导致了表面显示的抗原的免疫原性和功效的显着改善。此外，据报道，一些有希望的临床前结果镜像杆状病毒的范围和实用性作为在不久的将来的人类应用的疫苗载体。本文，本综述概述了杆状病毒表面显示疫苗对动物模型中的嗜血杆菌和其他传染病的诱导的免疫应答，并突出了应用于增强针对显示的抗原的保护性免疫应答的策略。
Balraj Premanand; Poh Zhong Wee;Mookkan Prabakaran[ [*]. Baculovirus Surface Display of Immunogenic Proteins for Vaccine Development[J]. Viruses, 2018,10(6): 298